PMID: 558284May 1, 1977Paper

Plasma tryptophan levels and brain serotonin metabolism in chronically uremic rats

The Journal of Nutrition
F SiassiM E Swendseid

Abstract

Plasma tryptophan (Trp) levels and brain concentrations of Trp, serotonin, and 5-hydroxyindoleacetic acid (5-HIAA) were measured in chronically uremic rats fed either 11% or 18% casein diets for 8 to 12 weeks. Uremic rats had increased levels of plasma urea nitrogen and 5-HIAA when compared with sham-operated pair-fed controls. The level of plasma total Trp decreased in both uremic groups and the level of plasma free Trp increased only in those fed an 11% casein diet. Uremic rats fed 11% casein had a higher level of plasma free Trp than those fed 18% casein. The ratio of plasma total Trp to the sum of five amino acids competing for the blood-brain transport system was decreased in both uremic groups, and the ratio of plasma free Trp to the same amino acids was increased only in uremic rats fed 11% casein. The concentration of brain 5-HIAA increased in uremic rats fed 11% casein, and that of Trp and serotonin decreased in uremic rats fed 18% casein. These results indicate that uremic stress and changes in protein intake in chronic uremia alter plasma Trp levels and brain serotonin metabolism.

Citations

Sep 4, 2018·European Journal of Clinical Investigation·Daphne HahnFrank Gruenhage
Aug 7, 1978·Acta Neuropathologica·K JellingerP Kothbauer
Sep 1, 2000·American Journal of Physiology. Renal Physiology·K SaitoM Seishima
Jan 14, 2004·Seminars in Dialysis·Abelardo AguileraRafael Selgas
Nov 16, 2013·Analytical and Bioanalytical Chemistry·Toshihiro KobayashiMasahiro Kohno
Jul 1, 1978·Journal of Neurology, Neurosurgery, and Psychiatry·P A SullivanG Curzon

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