Plasma tumor necrosis factor soluble receptors in chronic renal failure

Kidney International
M BrockhausN Haran

Abstract

Two soluble tumor necrosis factor receptors (sTNFRs) were detected in the plasma of patients with different degrees of chronic renal failure (CRF) and of long-term hemodialysis (HD) patients. In uremic undialyzed patients, plasma levels of both sTNFRs increased progressively with declining renal function. A linear correlation was found between sTNFR plasma levels and plasma creatinine concentration. sTNFR levels in end-stage uremic patients shortly before commencement of first HD treatment were approximately tenfold higher than in normal subjects. Long-term HD patients showed a further increase in plasma sTNFRs. The origin of sTNFRs, as well as their physiological role remains to be elucidated.

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Related Concepts

Hemodialysis
Necrosis
Kidney Function Tests
Tumor Necrosis Factor-alpha
Tumor Necrosis Factor Receptor
Hormone Receptors, Cell Surface
Kidney
Renal Insufficiency
Soluble
Kidney Failure, Chronic

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