Plasma tumor necrosis factor soluble receptors in chronic renal failure

Kidney International
M BrockhausN Haran


Two soluble tumor necrosis factor receptors (sTNFRs) were detected in the plasma of patients with different degrees of chronic renal failure (CRF) and of long-term hemodialysis (HD) patients. In uremic undialyzed patients, plasma levels of both sTNFRs increased progressively with declining renal function. A linear correlation was found between sTNFR plasma levels and plasma creatinine concentration. sTNFR levels in end-stage uremic patients shortly before commencement of first HD treatment were approximately tenfold higher than in normal subjects. Long-term HD patients showed a further increase in plasma sTNFRs. The origin of sTNFRs, as well as their physiological role remains to be elucidated.


Oct 23, 1997·International Journal of Cancer. Journal International Du Cancer·M MalejczykJ Malejczyk
Jan 1, 1995·Transplant International : Official Journal of the European Society for Organ Transplantation·J F LeeuwenbergW A Buurman
May 1, 1997·Transplantation Proceedings·W RebhandlF Stockenhuber
Sep 30, 1998·British Journal of Haematology·T KitohS Nakagawa
Oct 3, 2002·Seminars in Dialysis·Wim Van BiesenNorbert Lameire
Oct 3, 2002·Seminars in Dialysis·P Stenvinkel, Anders Alvestrand
Feb 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A CortiG Cassani
Jan 6, 2012·British Journal of Anaesthesia·N ArulkumaranM Singer
Nov 23, 2012·British Journal of Anaesthesia·N ArulkumaranM Singer
Oct 6, 2005·Current Opinion in Nephrology and Hypertension·Darren Yuen, Christopher T Chan
Dec 14, 2007·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Hiroshi AdachiTakashi Joh
Dec 17, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Monika A NiewczasAndrzej S Krolewski
Aug 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B J PereiraC A Dinarello
Nov 11, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Frank GrünhageChristoph Reichel
Oct 19, 2004·Seminars in Nephrology·Gianfranco GuarnieriRocco Barazzoni
Dec 25, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jose IglesiasNorasept II Study Investigators
Jan 15, 2009·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Sung-Won ParkYong-Lim Kim
May 13, 2009·Hemodialysis International·Lakhmir S Chawla, Mahesh Krishnan
Aug 26, 1998·Rheumatic Diseases Clinics of North America·L W Moreland
Apr 1, 1997·Clinical Immunology and Immunopathology·M Winter
Feb 4, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·B C SantosN Schor
Sep 1, 1995·JPEN. Journal of Parenteral and Enteral Nutrition·M E KeithK N Jeejeebhoy
Mar 8, 2018·Seminars in Dialysis·Kristen L Nowak, Michel Chonchol
Nov 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H TilgC A Dinarello
Jan 18, 2017·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Willie M LüdemannJulia Ranzinger
Oct 30, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S H ChungB Lindholm


Jan 1, 1991·Nephron·S PaydaşA A Gürçay
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M BrockhausH Loetscher
Aug 1, 1990·The Journal of Experimental Medicine·F Porteu, C Nathan
Jan 1, 1990·Kidney International·R SchindlerC A Dinarello
Jan 1, 1989·Annual Review of Immunology·B Beutler, A C Cerami
Apr 1, 1988·The Journal of Experimental Medicine·P SeckingerJ M Dayer
Jan 1, 1987·Blood Purification·L W Henderson, D E Chenoweth
Mar 1, 1988·The Journal of Experimental Medicine·K J TraceyA C Cerami
Oct 24, 1986·Science·K J TraceyJ D Albert
Dec 1, 1983·Kidney International·D E ChenowethL W Henderson

Related Concepts

Kidney Function Tests
Tumor Necrosis Factor-alpha
Tumor Necrosis Factor Receptor
Hormone Receptors, Cell Surface
Renal Insufficiency
Kidney Failure, Chronic

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