Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis.

The Lancet. Diabetes & Endocrinology
Jon WhiteUCLEB (University College London-London School of Hygiene & Tropical Medicine-Edinburgh-Bristol Consortium

Abstract

Increased circulating plasma urate concentration is associated with an increased risk of coronary heart disease, but the extent of any causative effect of urate on risk of coronary heart disease is still unclear. In this study, we aimed to clarify any causal role of urate on coronary heart disease risk using Mendelian randomisation analysis. We first did a fixed-effects meta-analysis of the observational association of plasma urate and risk of coronary heart disease. We then used a conventional Mendelian randomisation approach to investigate the causal relevance using a genetic instrument based on 31 urate-associated single nucleotide polymorphisms (SNPs). To account for potential pleiotropic associations of certain SNPs with risk factors other than urate, we additionally did both a multivariable Mendelian randomisation analysis, in which the genetic associations of SNPs with systolic and diastolic blood pressure, HDL cholesterol, and triglycerides were included as covariates, and an Egger Mendelian randomisation (MR-Egger) analysis to estimate a causal effect accounting for unmeasured pleiotropy. In the meta-analysis of 17 prospective observational studies (166 486 individuals; 9784 coronary heart disease events) a 1 SD higher...Continue Reading

References

Jul 10, 2002·Circulation·Ulf Landmesser, Helmut Drexler
May 12, 2009·BMC Bioinformatics·Eric JainElisabeth Gasteiger
Jan 5, 2010·Nature Reviews. Rheumatology·Robert Terkeltaub
Aug 13, 2011·Journal of the American College of Cardiology·Narasimharajapura S RajendraAllan D Struthers
Dec 23, 2011·Kidney International·Afshin ParsaPatrick F McArdle
Mar 17, 2012·Lancet·UNKNOWN Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) ConsortiumJuan Pablo Casas
Jul 18, 2012·Heart·Allan Struthers, Fiona Shearer
Oct 26, 2013·International Journal of Epidemiology·Marie-Jo A BrionPeter M Visscher
Nov 12, 2013·Nucleic Acids Research·A Patrícia BentoJohn P Overington
Sep 23, 2014·Bioinformatics·Andrew YatesPaul Flicek
Jan 30, 2015·American Journal of Epidemiology·Stephen Burgess, Simon G Thompson
Jun 8, 2015·International Journal of Epidemiology·Jack BowdenStephen Burgess

❮ Previous
Next ❯

Citations

Jan 20, 2016·The Lancet. Diabetes & Endocrinology·Stephen Burgess
Oct 30, 2016·Lancet·Nicola DalbethLisa K Stamp
Jun 25, 2016·Clinical and Experimental Nephrology·Takanori KumagaiShunya Uchida
Jun 28, 2016·International Journal of Epidemiology·Daniel I SwerdlowAroon D Hingorani
Jul 15, 2016·Nature Reviews. Rheumatology·Philip C RobinsonTony R Merriman
Jun 18, 2017·Revista Española De Cardiología·Roberto Elosua, Sergi Sayols-Baixeras
Dec 19, 2017·International Journal of Epidemiology·A F Schmidt, F Dudbridge
Dec 23, 2017·Rheumatology·Pascal RichetteThomas Bardin
Jun 21, 2018·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M S SantanaF C Meotti
May 18, 2018·Human Molecular Genetics·Gibran HemaniGeorge Davey Smith
Jul 18, 2018·Annals of Neurology·Camilla J KobyleckiShoaib Afzal
Nov 3, 2017·Open Biology·Sophie Hackinger, Eleftheria Zeggini
Apr 22, 2017·Clinical Chemistry·Camilla J KobyleckiBørge G Nordestgaard
Dec 12, 2019·Nature Reviews. Rheumatology·Leo A B JoostenRichard J Johnson
May 21, 2017·European Journal of Epidemiology·Stephen Burgess, Simon G Thompson
Nov 23, 2017·European Journal of Preventive Cardiology·Davide LazzeroniPaolo Coruzzi
May 10, 2017·Current Atherosclerosis Reports·Ben LaceyJane Armitage
Dec 19, 2017·International Journal of Clinical Practice·Anastazia KeiMoses Elisaf
Dec 2, 2017·The European Respiratory Journal·Ma'en ObeidatUNKNOWN International COPD Genetics Consortium, Lung eQTL Consortium, Lung Health Study
Jan 19, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Satoko SakataToshiharu Ninomiya
Aug 11, 2020·Wellcome Open Research·Stephen BurgessEvropi Theodoratou
Jun 16, 2018·Frontiers in Medicine·Caroline L BennCiara Vangjeli
Mar 20, 2019·BMC Rheumatology·Seoyoung C KimDaniel H Solomon
Oct 19, 2017·International Journal of Epidemiology·Fernando Pires HartwigJack Bowden
May 10, 2018·Nature Reviews. Rheumatology·Tanya J MajorTony R Merriman

❮ Previous
Next ❯

Software Mentioned

GIANT
Ensembl Rest API
metafor
ChEMBL
AmiGO

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.