Plasma & urinary catecholamines & urinary vanillylmandelic acid levels in patients with generalized vitiligo

The Indian Journal of Medical Research
Binamra BasnetSomesh Gupta

Abstract

Vitiligo is an acquired skin disease characterized by depigmented areas of the skin. Increased release of catecholamines from autonomic nerve endings in microenvironment of melanocytes in affected skin might be involved in the aetiopathogenesis of vitiligo. Levels of catecholamines are considered as being related to onset or worsening of the disease. Therefore, in this study, the role of catecholamines was evaluated in mapping disease stability and outcome of vitiligo patients undergoing melanocyte transfer. In this study, circulatory and urinary levels of catecholamine (CA) and vanillylmandelic acid (VMA) were determined in 45 individuals (30 vitiligo patients and 15 healthy controls) using ELISA. A significant increase for plasma and urinary catecholamines along with VMA was observed as compared to healthy controls. When the pre- and post-intervention levels were analyzed in responders and non-responders, respectively, only dopamine showed significant decline in urine, rest of the molecules in plasma as well as urine showed non-significant decline except VMA which showed insignificant increase. Levels of plasma/urinary epinephrine, and plasma dopamine, could not be established as biomarkers for disease stability or successful...Continue Reading

Citations

Oct 24, 2020·Scientific Reports·Wei LiuDong-Lai Ma
Mar 20, 2021·Frontiers in Immunology·Erica L Katz, John E Harris
Aug 8, 2021·International Journal of Molecular Sciences·Enkhmend Enkhtaivan, Chang Hoon Lee

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