Abstract
To detect plasma vascular endothelial growth factor B (VEGF-B) in individuals with different glucose tolerance and investigate the relationship between plasma VEGF-B levels and the first phase of glucose-stimulated insulin secretion. A cross-sectional study was conducted involving 45 patients with newly diagnosed type 2 diabetes mellitus (T2DM), 37 patients with impaired glucose regulation (IGR), and 39 Normal glucose tolerance (NGT) subjects, all of whom underwent intravenous glucose tolerance test. Plasma VEGF-B levels were assayed by ELISA. The first phase of insulin secretion was evaluated by acute insulin response (AIR), the area under the curve of the first-phase (0-10 min) insulin secretion (AUC) and glucose disposition index (GDI). The T2DM and IGR groups had higher plasma VEGF-B levels than the NGT group (P < 0.01). Plasma VEGF-B levels were negatively correlated with AIR, AUC, GDI, HOMA-β (P < 0.01), and positively correlated with plasma glucose, HbA1c, triglyceride, free fatty acid (FFA), fasting insulin, and HOMA-IR (P < 0.01). Logistic regression analysis revealed that higher VEGF-B levels [145.59-180.07 pg/ml, OR 3.55 (95% CI 1.05-12.02) and >180.07 pg/ml, OR 3.64 (95% CI 1.16-11.42)] were related to a greater pro...Continue Reading
References
Oct 1, 1986·Computer Methods and Programs in Biomedicine·G Pacini, R N Bergman
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y LeeR H Unger
Feb 1, 1994·The Journal of Clinical Investigation·Y P Zhou, V E Grill
Nov 1, 1993·Diabetes·S E KahnJ P Palmer
Aug 9, 1996·The Journal of Biological Chemistry·B OlofssonU Eriksson
Aug 1, 1998·Diabetic Medicine : a Journal of the British Diabetic Association·K G Alberti, P Z Zimmet
Sep 24, 1999·The Journal of Clinical Investigation·C WeyerR E Pratley
Jun 26, 2001·Diabetes/metabolism Research and Reviews·S Del Prato, A Tiengo
Sep 28, 2001·Diabetes·A VirkamäkiH Yki-Järvinen
Jan 5, 2002·Diabetes·J Denis McGarry
Dec 28, 2002·Diabetes·Johanna KuhlmannAndreas W Herling
Nov 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Michael RosenbaumUNKNOWN Camino Diabetes Prevention Group
Sep 2, 2008·Circulation Research·Terhi KarpanenKari Alitalo
Dec 17, 2009·Molecular Neurodegeneration·Torsten FalkScott J Sherman
Mar 17, 2010·Nature·Carolina E HagbergUlf Eriksson
Jul 7, 2010·Cell Cycle·Zahidur R AbedinE Premkumar Reddy
May 20, 2011·The Biochemical Journal·Julien VéretHervé Le Stunff
Aug 14, 2012·Molecular and Cellular Endocrinology·Mohammed BensellamJean-Christophe Jonas
Oct 2, 2012·Nature·Carolina E HagbergUlf Eriksson
May 4, 2013·Diabetes & Metabolism Journal·Udayakumar Karunakaran, Keun-Gyu Park
Oct 9, 2013·The Biochemical Journal·Jonathan Barlow, Charles Affourtit
Aug 30, 2014·Scientific Reports·M H DijkstraS Ylä-Herttuala
Apr 21, 2016·Journal of Endocrinological Investigation·V GhorbanzadehG Mohaddes
Citations
May 21, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Glenn C Rowe, Martin E Young
Sep 20, 2019·PloS One·Jan Benedikt GroenerStefan Kopf
Feb 13, 2018·Oncotarget·Lingli LongYubin Li
Aug 9, 2018·Diabetology & Metabolic Syndrome·Mohammad Ishraq ZafarLu-Lu Chen
Jan 24, 2020·Scientific Reports·Frank Chenfei NingDaniel Nyqvist
Sep 22, 2020·American Journal of Physiology. Endocrinology and Metabolism·Xiaodan LuLulu Chen
Apr 24, 2021·World Journal of Diabetes·Jing-Dan JiaYa-Na Li