Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations.

Diabetes Care
Ju-Sheng ZhengNicholas J Wareham

Abstract

Higher plasma vitamin C levels are associated with lower type 2 diabetes risk, but whether this association is causal is uncertain. To investigate this, we studied the association of genetically predicted plasma vitamin C with type 2 diabetes. We conducted genome-wide association studies of plasma vitamin C among 52,018 individuals of European ancestry to discover novel genetic variants. We performed Mendelian randomization analyses to estimate the association of genetically predicted differences in plasma vitamin C with type 2 diabetes in up to 80,983 case participants and 842,909 noncase participants. We compared this estimate with the observational association between plasma vitamin C and incident type 2 diabetes, including 8,133 case participants and 11,073 noncase participants. We identified 11 genomic regions associated with plasma vitamin C (P < 5 × 10-8), with the strongest signal at SLC23A1, and 10 novel genetic loci including SLC23A3, CHPT1, BCAS3, SNRPF, RER1, MAF, GSTA5, RGS14, AKT1, and FADS1. Plasma vitamin C was inversely associated with type 2 diabetes (hazard ratio per SD 0.88; 95% CI 0.82, 0.94), but there was no association between genetically predicted plasma vitamin C (excluding FADS1 variant due to its app...Continue Reading

References

Jul 28, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Anette KarlsenThomas E Gundersen
Aug 24, 2007·Statistical Methods in Medical Research·Vanessa Didelez, Nuala Sheehan
Apr 25, 2009·Journal of the American Society of Nephrology : JASN·Sakarn BunnagPhilip F Halloran
Jul 10, 2010·Bioinformatics·Cristen J WillerGonçalo R Abecasis
Apr 3, 2012·Lancet·Rory Collins
Mar 20, 2013·Molecular Aspects of Medicine·Marc BürzleMatthias A Hediger
May 21, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ho Sung LeeJi Hoon Jeong
Oct 12, 2013·Genetic Epidemiology·Stephen BurgessSimon G Thompson
Jun 8, 2015·International Journal of Epidemiology·Jack BowdenStephen Burgess
Mar 17, 2016·Advances in Nutrition·Mandana Amir ShaghaghiPeter Eck

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Citations

Jun 1, 2021·European Journal of Preventive Cardiology·Shuai YuanSusanna C Larsson
May 18, 2021·Frontiers in Cell and Developmental Biology·Kristina Y Aguilera, David W Dawson
Nov 20, 2021·Journal of the American Heart Association·Leon G MartensDiana van Heemst

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Methods Mentioned

BETA
Genotyping
phosphotransferase
1

Software Mentioned

SNPTEST
METAL
R
Stata
MAGENTA
DEPICT
R Foundation for Statistical Computing
DIAMANTE
InterAct
DIAbetes

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