PMID: 9174484Jun 1, 1997Paper

Plasma vitamin C concentrations in patients with cystic fibrosis: evidence of associations with lung inflammation

The American Journal of Clinical Nutrition
B M Winklhofer-RoobD H Shmerling

Abstract

Vitamin C status and possible associations with the disease process in cystic fibrosis (CF) patients were investigated. Plasma vitamin C concentrations in patients from two different mid-European populations (Swiss, n = 62; Austrian, n = 60) taking no or low-dose vitamin C from multivitamin supplements did not differ from each other or from control subjects (n = 34). Vitamin C concentrations decreased with age (5.05 mumol.L-1, y-1). When followed up for 12 mo, patients had the highest plasma vitamin C concentrations in February and the lowest in May and August (P < 0.01); the decrease in vitamin C was accompanied by increases in plasma malondialdehyde (P < 0.001) and tumor necrosis factor alpha concentrations (P < 0.01). During supplementation with vitamin E for 2 mo or beta-carotene for 12 mo vitamin C concentrations did not change. They correlated inversely with white blood cell count (r = -0.36, P = 0.008), bands (r = -0.36, P = 0.02), alpha 1-acid glycoprotein (r = -0.45, P = 0.002), interleukin 6 (r = -0.46, P = 0.0006), and neutrophil elastase/alpha 1-proteinase inhibitor complexes (r = -0.34, P = 0.02). In patients with vitamin C concentrations < 40 mumol/L, all indexes of inflammation were relatively high, whereas those...Continue Reading

Citations

Mar 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Horst FischerBeate Illek
Jul 28, 2004·The American Journal of Clinical Nutrition·Evelyn I BackHans K Biesalski
Jul 17, 2009·The British Journal of Nutrition·P C CalderJ Zhao
Dec 29, 2000·Annals of the New York Academy of Sciences·W Fawzi
May 31, 2002·The American Journal of Clinical Nutrition·Michele L Dreyfuss, Wafaie W Fawzi
Feb 8, 2007·The American Journal of Clinical Nutrition·Paul K DrainWafaie W Fawzi
May 7, 2020·American Journal of Respiratory Cell and Molecular Biology·Adegboyega Timothy AdewaleSteven M Rowe
May 15, 2001·Journal of the American College of Nutrition·L G WoodM L Garg
Jun 12, 2008·Clinical Reviews in Allergy & Immunology·David P NicholsJames F Chmiel
Aug 8, 2014·The Cochrane Database of Systematic Reviews·Oana Ciofu, Jens Lykkesfeldt
Nov 30, 2005·The Proceedings of the Nutrition Society·Frank J Kelly
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Dec 19, 2002·European Journal of Clinical Investigation·G SchippingerG Halwachs
Mar 7, 2000·Journal of the American Society of Nephrology : JASN·Johannes M RoobBrigitte M Winklhofer-Roob
Jun 22, 1999·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·S R KearnsD Bouchier-Hayes
Oct 7, 2004·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·M SinaasappelG Döring
Feb 9, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lisa G WoodManohar L Garg
Oct 6, 1998·Clinics in Chest Medicine·M W Konstan

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