PMID: 2507833Jan 1, 1989Paper

Plasma volume expansion and PEEP in a canine model of acute Pseudomonas pneumonia

Lung
P Hanly, R B Light

Abstract

Four groups of anesthetized, ventilated dogs (n = 6 in each group) inoculated endotracheally with Pseudomonas aeruginosa were studied over 5 h as bilateral, hemorrhagic pneumonia developed. Groups I and II were ventilated with zero end-expiratory pressure (ZEEP) and groups III and IV with positive end-expiratory pressure (PEEP) (8 cmH2O). Hetastarch (6%) in saline was infused intravenously to maintain similar transmural pulmonary wedge pressures (Pwtm) in groups I and III (approximately 5 mmHg) and groups II and IV (approximately 10 mmHg) throughout the experiment. The effects of plasma volume expansion were analyzed by comparing groups I and III with groups II and IV and of PEEP by comparing groups I and II with groups III and IV. The number of lobes with gross consolidation was greater in groups II (4.8 +/- 1.2) and IV (5 +/- 0.9) than in groups I (2 +/- 1.1) and III (3.3 +/- 1). The mean lung wet weight/body weight ratio was greater in groups II (40 +/- 11 g/kg) and IV (48 +/- 12 g/kg) than in groups I (19 +/- 3 g/kg) and III (32 +/- 6 g/kg) and in groups III and IV than in groups I and II. Plasma volume expansion, in the absence of PEEP (group II vs. group I), dramatically increased intrapulmonary shunt (Qs/Qt 5 h after ino...Continue Reading

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Citations

Sep 5, 2001·ILAR Journal·Borna Mehrad, Theodore J. Standiford
Jan 16, 2008·Current Opinion in Critical Care·Jerónimo Graf, John J Marini
Jan 1, 1990·Critical Reviews in Biochemistry and Molecular Biology·L BirnbaumerA M Brown
Jun 17, 2021·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Alexander G BobrovVlado Antonic

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