Plasma von Willebrand factor, soluble thrombomodulin, and fibrin D-dimer concentrations in acute onset non-rheumatic atrial fibrillation

Heart
Francisco MarínGregory Y H Lip

Abstract

To investigate whether new onset acute atrial fibrillation (AF) of < 48 hours' duration creates a prothrombotic state in the absence of anticoagulation and to assess the evolution in research indices after spontaneous or pharmacological cardioversion. 24 patients were recruited with first onset acute non-rheumatic AF, in whom sinus rhythm was restored within 48 hours of arrhythmia onset, without anticoagulant treatment. Atrial mechanical function was assessed by transmitral inflow. Soluble thrombomodulin and von Willebrand factor concentrations (both as indices of endothelial damage or dysfunction) and fibrin D-dimer concentrations (as an index of thrombogenesis) were measured. Blood samples were drawn and echocardiographic studies were performed at days 1, 3, 7, and 30 after cardioversion. Research indices were compared with those of 24 healthy participants, 24 patients with chronic AF, and 24 patients with ischaemic heart disease in sinus rhythm. Patients with AF had higher concentrations of soluble thrombomodulin (acute AF 12.1 (4.1) ng/ml; chronic AF 11.8 (4.6) ng/ml), von Willebrand factor (acute AF 137.2 (36.9) ng/ml; chronic AF 133.1 (25.0) ng/ml), and fibrin D-dimer concentrations (acute AF 2.35 (2.68) microg/ml; chroni...Continue Reading

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Citations

Feb 4, 2012·Journal of Thrombosis and Thrombolysis·Mónica AcevedoCarlos Navarrete
May 26, 2005·Current Hypertension Reports·George I Varughese, Gregory Y H Lip
Apr 26, 2006·Current Treatment Options in Cardiovascular Medicine·Cathy M Helgason
Jun 2, 2005·Thrombosis Research·Gregory Y H Lip, Bethan Freestone
Feb 7, 2013·European Heart Journal·Ziad HijaziLars Wallentin
Mar 30, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Petri KorkeilaJuhani Airaksinen
Jan 10, 2014·Current Treatment Options in Cardiovascular Medicine·Eduard Shantsila, Gregory Y H Lip
Jul 19, 2011·Current Opinion in Cardiology·Jasper J BrugtsMarcel J M Kofflard
Oct 6, 2006·Expert Opinion on Pharmacotherapy·Stéphane Ederhy, Ariel Cohen
Aug 28, 2009·Annals of Medicine·Suresh KrishnamoorthyGregory Y H Lip
Dec 3, 2014·International Journal of Cardiology·Nathan E K ProcterUNKNOWN SAFETY Investigators
Sep 24, 2013·Heart Failure Clinics·Eduard Shantsila, Gregory Y H Lip
Aug 22, 2013·The Canadian Journal of Cardiology·Jelena KornejGregory Y H Lip
Dec 23, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Nathan E K ProcterJohn D Horowitz
Aug 2, 2011·Thrombosis Research·Silvia Montoro-GarcíaGregory Y H Lip
May 8, 2010·International Journal of Cardiology·Hugo VerdejoRamon Corbalan
Mar 9, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Scott R WilloughbyPrashanthan Sanders
Aug 19, 2007·Thrombosis Research·Arnljot TveitHarald Arnesen
Oct 19, 2006·Journal of the American College of Cardiology·Christopher J BoosAndrew D Blann
Jul 6, 2011·International Journal of Cardiology·Chee W KhooGregory Y H Lip
Feb 18, 2014·The American Journal of Cardiology·Daniel S IcePeter R Kowey
Dec 10, 2009·Korean Circulation Journal·Boris Leithäuser, Jai-Wun Park
Jun 21, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Andreas GoetteStanley Nattel
Sep 3, 2016·Journal of Arrhythmia·Andreas GoetteUNKNOWN Review coordinator: Alena Shantsila (UK)
Jul 13, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Andreas GoetteUNKNOWN Document Reviewers:
Jun 18, 2016·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Mariya NegrevaKaterina Vitlianova
Jan 5, 2018·Thrombosis Journal·Anja Wiedswang HorjenArnljot Tveit
May 16, 2018·Herzschrittmachertherapie & Elektrophysiologie·Jelena KornejGerhard Hindricks
Nov 6, 2018·Cardiovascular Research·Ahsan A Khan, Gregory Y H Lip
Nov 10, 2005·European Heart Journal·Christopher J BoosGregory Y H Lip
Oct 19, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Anetta Undas
Nov 5, 2016·Clinical Chemistry·Ziad HijaziLars Wallentin
Jan 23, 2019·Frontiers in Physiology·Alessandra AlíAdemuyiwa S Aromolaran
Aug 6, 2020·Journal of Clinical Medicine·Paweł T MatusikAnetta Undas

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