Plasmablastic lymphoma: current perspectives

Blood and Lymphatic Cancer : Targets and Therapy
Andres Lopez, Pau Abrisqueta

Abstract

Plasmablastic lymphoma (PbL) is a rare and aggressive B-cell malignancy with large neoplastic cells, most of them resembling plasmablasts that have a CD20-negative phenotype. Although initially described as being associated with HIV, over the years it has also been identified in patients with solid organ transplant and immunocompetent patients. Little is known about molecular basis that drives PbL, and still its diagnosis remains challenging given its rarity. However, proper recognition of its clinical characteristics, localization, and morphological features can establish a correct diagnosis of PbL within the spectrum of CD20-negative large B-cell lymphomas (LBCLs). PbL is characterized by CD20 and PAX5 negativity together with the expression of CD38, CD138, MUM1/IRF4, Blimp1, and XBP1 plasmacytic differentiation markers. It is usually associated with Epstein-Barr virus infections, and MYC gene rearrangements. PbL should be carefully differentiated from other CD20-negative B-cell neoplasms, ie, primary effusion lymphoma, anaplastic lymphoma kinase-positive (ALK) large B-cell lymphoma, and LBCL in human herpesvirus 8-associated multicentric Castleman disease. Despite our improved understanding of this disease, its prognosis rem...Continue Reading

Citations

Mar 20, 2020·Journal of Oral and Maxillofacial Pathology : JOMFP·Revati DeshmukhHarshal Varpe
Jun 2, 2020·Clinical Case Reports·Ashlyn Rui Yin CheeMichael F Leahy
Dec 20, 2020·The Kaohsiung Journal of Medical Sciences·Ya-Lun KeChun-Chieh Wu
Nov 19, 2019·Pathology·Narittee SukswaiL Jeffrey Medeiros
Feb 19, 2021·Clinical Case Reports·Manthan KathrotiyaReena Nair
Apr 3, 2021·Clinical Journal of Gastroenterology·Syamim JohanNornazirah Azizan
May 9, 2021·Current Gastroenterology Reports·Sara SmallReem Karmali
May 26, 2021·Journal of Investigative Medicine High Impact Case Reports·Kemnasom NwanweneMohamed Alsharedi
Aug 28, 2021·Cancers·Julius Maximilian KnerrMette Marie Rosenkilde
Oct 7, 2021·Leukemia & Lymphoma·Amsha RamburanDhirendra Govender

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Methods Mentioned

BETA
ICE

Clinical Trials Mentioned

NCT01192464

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