Plasmacytoid dendritic cell leukemia: a rapidly evolving disease presenting with skin lesions sensitive to radiotherapy plus hyperthermia

The Oncologist
Cristina TecchioGiampiero Girolomoni

Abstract

Plasmacytoid dendritic cell leukemia (pDCL) is a rapidly evolving disease, which frequently presents with skin lesions, particularly nodules and plaques with a typical reddish-brown or brown color. Treatment of pDCL is based on multiagent chemotherapy followed by allogeneic hematopoietic stem cell transplant, but skin lesions may be refractory to therapy. Here, we report on a 61-year-old patient affected by pDCL who first presented with multiple cutaneous nodules and plaques on the trunk. Lesions showed an excellent response to radiotherapy plus hyperthermia. Although this treatment did not avoid the systemic evolution of disease, it resolved skin lesions and prevented their relapse, thus representing a therapeutic option to be used in combination with chemotherapy regimens. The case presentation is followed by a general discussion with an emphasis on the diagnosis and treatment of this rare malignancy.

References

Mar 1, 1990·International Journal of Radiation Oncology, Biology, Physics·I A Petersen, D S Kapp
Feb 28, 2002·Blood·Jean FeuillardMarie-Christine Béné
Sep 18, 2003·Bone Marrow Transplantation·P ReimerM Wilhelm
Feb 5, 2005·Blood·Rein WillemzeChris J L M Meijer
Jun 29, 2005·American Journal of Clinical Pathology·Tony PetrellaMichael A Teitell
Apr 19, 2007·American Journal of Clinical Pathology·Marco Herling, Dan Jones
Jan 26, 2008·Blood·Teresa MarafiotiDavid Y Mason
Apr 9, 2008·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Hunter R Moyer, Keith A Delman
May 23, 2008·Journal of Cutaneous Pathology·Stefano AscaniLorenzo Cerroni
Apr 25, 2009·British Journal of Haematology·Francine Garnache-OttouUNKNOWN GOELAMS and GEIL study
Jun 11, 2009·Clinical and Experimental Dermatology·J FontaineS Dalle

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Citations

Oct 20, 2011·Advanced Materials·María Vallet-Regí, Eduardo Ruiz-Hernández

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