Plasmacytoid dendritic cells and Th17 immune response contribution in gastrointestinal acute graft-versus-host disease

Leukemia
Céline BossardBéatrice Gaugler

Abstract

The contribution of Th17 cells in acute graft-versus-host disease (aGVHD) has been demonstrated in aGVHD mouse models. However, their contribution in human gastrointestinal aGVHD remains unclear. We evaluated Th17 cells in a cohort of 23 patients at diagnosis of aGVHD. In this study, we have shown that the absolute number of Th17 cells using the CCR6 and CD161 markers were significantly higher in the intestinal mucosa of patients with aGVHD compared with intestinal mucosa of patients without aGVHD. Moreover, in keeping with the increase of CCR6+ and CD161+ T cells, RORγt the key transcription factor that orchestrates the differentiation of Th17 cells, was significantly increased in the intestinal mucosa of patients with aGVHD compared with intestinal mucosa of patients without aGVHD (P=0.01). Since plasmacytoid dendritic cells (PDCs) have been reported to drive the differentiation of the Th17 subset, we quantified PDCs in these patients. PDC CD123+ cells were increased in the intestinal mucosa of patients with aGVHD. Furthermore, the number of CD123+ PDCs paralleled the histological grade of aGVHD, providing evidence for a role of Th17-mediated responses and a potential new pathophysiological link between PDCs and Th17 in human...Continue Reading

References

Aug 1, 1979·The American Journal of Surgical Pathology·G E SaleE D Thomas
Aug 27, 1997·Transplantation·W KrengerJ L Ferrara
Nov 30, 2006·Annual Review of Immunology·Lisbeth A WelniakWilliam J Murphy
May 9, 2007·Nature Immunology·Eva V Acosta-RodriguezGiorgio Napolitani
Jul 20, 2007·The Journal of Experimental Medicine·Francesco AnnunziatoSergio Romagnani
Oct 22, 2008·Blood·Lucy W KappelMarcel R M van den Brink
Jan 10, 2009·Annual Review of Immunology·Thomas KornVijay K Kuchroo
Mar 11, 2009·The Journal of Experimental Medicine·Melanie A KleinschekRobert A Kastelein
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Leslie van der FitsErik Lubberts
Jul 29, 2009·European Journal of Immunology·Magnus IsakssonAnna Lobell
Aug 26, 2009·The Journal of Experimental Medicine·Dipyaman GangulyMichel Gilliet
Oct 7, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Cristina IclozanXue-Zhong Yu
Dec 23, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chun-Feng YuNatalija Novak
May 21, 2010·Blood·Philippe RatajczakGérard Socié
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kiran NistalaLucy R Wedderburn
Nov 20, 2010·Blood·Leonidas C Platanias
Dec 1, 2010·The Journal of Experimental Medicine·Josh GregorioMichel Gilliet
Dec 1, 2010·The Journal of Experimental Medicine·Cristiana GuiducciFranck J Barrat
Feb 1, 2011·Nature Immunology·Keiji HirotaBrigitta Stockinger
Apr 27, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francis BonnefoySylvain Perruche
Jul 19, 2011·Nature·Enric EspluguesRichard A Flavell

❮ Previous
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Citations

Apr 12, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Zinaida PericMohamad Mohty
Nov 20, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Walter J F M van der VeldenNicole M A Blijlevens
Mar 21, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Matheus Vescovi GonçalvesCelso Arrais Rodrigues
Feb 26, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Anniek B van der WaartHarry Dolstra
May 6, 2016·Frontiers in Immunology·Baptiste LamarthéeBéatrice Gaugler
Dec 5, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Felix BahrSebastian Tuve
Dec 30, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sung-Eun LeeChang-Ki Min
Oct 22, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Dror MevorachReuven Or
Jan 30, 2018·The Journal of Clinical Investigation·Defu Zeng
Nov 7, 2018·Doklady. Biochemistry and Biophysics·T A BogushS A Tjulandin
Dec 30, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lijun MengYi Zhang
Jun 4, 2020·Clinical & Translational Immunology·Yishan YeFlorent Malard
Sep 26, 2014·Cancer Research·Leslie GuéryStéphanie Hugues
Sep 4, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Alexander KroemerThomas M Fishbein
Oct 21, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Lijun MengYi Zhang
Oct 17, 2018·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Loïc DelensSophie Servais
Aug 17, 2021·Frontiers in Immunology·Nicholas J HessChristian M Capitini

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