Plasmacytoid dendritic cells in multiple sclerosis: chemokine and chemokine receptor modulation by interferon-beta.

Journal of Neuroimmunology
Latt Latt AungKonstantin E Balashov

Abstract

Plasmacytoid dendritic cells (pDCs) are present in peripheral blood, leptomeninges and demyelinating lesions in patients with multiple sclerosis (MS). The ability of pDCs to produce chemokines and express the chemokine receptor CCR7 in MS is not known. We studied pDCs in MS patients and healthy subjects. The ability of pDCs to up-regulate CCR7 was significantly increased in untreated MS patients as compared to healthy subjects. IFN-beta treatment significantly inhibited TLR9 agonist-specific secretion of chemokines, which are ligands for CCR5-positive Th1 cells (CCL3, CCL4, and CCL5), and impaired TLR9 agonist-induced up-regulation of CCR7 and IFN-alpha in MS patients. This finding represents a new immunomodulatory effect of IFN-beta in patients with multiple sclerosis.

Associated Clinical Trials

Citations

Dec 29, 2012·International Journal of Molecular Sciences·Mohammad G MohammadDavid A Brown
Nov 15, 2012·Immunotherapy·Felipe von GlehnKonstantin E Balashov
Jun 13, 2012·Journal of Neuroimmunology·Latt Latt AungKonstantin E Balashov
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Sep 24, 2013·JAK-STAT·Isabella RauchThomas Decker
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