Abstract
Plasmacytoid dendritic cells (pDCs) are present in peripheral blood, leptomeninges and demyelinating lesions in patients with multiple sclerosis (MS). The ability of pDCs to produce chemokines and express the chemokine receptor CCR7 in MS is not known. We studied pDCs in MS patients and healthy subjects. The ability of pDCs to up-regulate CCR7 was significantly increased in untreated MS patients as compared to healthy subjects. IFN-beta treatment significantly inhibited TLR9 agonist-specific secretion of chemokines, which are ligands for CCR5-positive Th1 cells (CCL3, CCL4, and CCL5), and impaired TLR9 agonist-induced up-regulation of CCR7 and IFN-alpha in MS patients. This finding represents a new immunomodulatory effect of IFN-beta in patients with multiple sclerosis.
Citations
Dec 29, 2012·International Journal of Molecular Sciences·Mohammad G MohammadDavid A Brown
Nov 15, 2012·Immunotherapy·Felipe von GlehnKonstantin E Balashov
Jun 13, 2012·Journal of Neuroimmunology·Latt Latt AungKonstantin E Balashov
Dec 17, 2014·Cytokine & Growth Factor Reviews·Martina SeveraEliana M Coccia
Sep 24, 2013·JAK-STAT·Isabella RauchThomas Decker
Mar 6, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Makoto HirotaniHidenao Sasaki
Feb 24, 2015·Mediators of Inflammation·Zhong-Xiang XieTao Jin
Mar 14, 2016·Cellular and Molecular Life Sciences : CMLS·Felix LuessiEsther Witsch
Sep 1, 2016·ACS Nano·Lisa H TostanoskiChristopher M Jewell
Nov 29, 2016·Nature Reviews. Immunology·Tim WorbsReinhold Förster
Sep 24, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Kristof ThewissenNathalie Cools
Feb 2, 2013·Multiple Sclerosis : Clinical and Laboratory Research·A H NuytsN Cools
Jan 18, 2018·Journal of Neuropathology and Experimental Neurology·Maxime De LaereNathalie Cools
Jan 7, 2016·Molecular Neurobiology·Lidia Fernández-ParedesSilvia Sánchez-Ramón
Nov 5, 2013·Biological Chemistry·Georgina Galicia, Jennifer L Gommerman
Dec 2, 2017·Clinical and Experimental Immunology·M PazhouhandehF Rahimi Jamnani
Jan 19, 2019·Biomaterials Science·Lisa H TostanoskiChristopher M Jewell
Aug 10, 2019·Neural Regeneration Research·Megha Meena, Nathalie Cools
Nov 30, 2020·The Journal of Nutritional Biochemistry·Xinli NiuJunpeng Wang