Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon

Nature Medicine
M CellaM Colonna

Abstract

We have identified two cell subsets in human blood based on the lack of lineage markers (lin-) and the differential expression of immunoglobulin-like transcript receptor 1 (ILT1) and ILT3. One subset (lin-/ILT3+/ILT1+) is related to myeloid dendritic cells. The other subset (lin-/ILT3+/ILT1+) corresponds to 'plasmacytoid monocytes'. These cells are found in inflamed lymph nodes in and around the high endothelial venules. They express CD62L and CXCR3, and produce extremely large amounts of type I interferon after stimulation with influenza virus or CD40L. These results, with the distinct cell phenotype, indicate that plasmacytoid monocytes represent a specialized cell lineage that enters inflamed lymph nodes at high endothelial venules, where it produces type I interferon. Plasmacytoid monocytes may protect other cells from viral infections and promote survival of antigen-activated T cells.

References

Oct 1, 1991·The American Journal of Surgical Pathology·F FacchettiP G Grigolato
Aug 1, 1990·Journal of Interferon Research·M Feldman, P Fitzgerald-Bocarsly
Jan 1, 1990·Biologicals : Journal of the International Association of Biological Standardization·T NedermanL Sjödin
Aug 1, 1990·The American Journal of Dermatopathology·F FacchettiV J Desmet
Jul 1, 1989·American Journal of Clinical Pathology·F FacchettiV J Desmet
May 1, 1989·The Journal of Pathology·F FacchettiV J Desmet
May 1, 1985·The American Journal of Surgical Pathology·E F PrasthoferC E Grossi
Dec 1, 1983·The American Journal of Surgical Pathology·H K Müller-HermelinkK Lennert
Sep 1, 1995·Immunology Today·J P Girard, T A Springer
Oct 1, 1993·Pharmacology & Therapeutics·P Fitzgerald-Bocarsly
Mar 3, 1997·The Journal of Experimental Medicine·L RoggeF Sinigaglia
May 1, 1997·European Journal of Immunology·P BjörckY J Liu
Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·J OlweusF Lund-Johansen
Apr 1, 1998·Nature·J Banchereau, R M Steinman
Oct 1, 1998·European Journal of Immunology·F SallustoA Lanzavecchia
Feb 2, 1999·The Journal of Experimental Medicine·P MarrackT Mitchell
Mar 2, 1999·The Journal of Experimental Medicine·M CellaA Lanzavecchia
Mar 17, 1999·The Journal of Experimental Medicine·A Hafezi-Moghadam, K Ley

❮ Previous
Next ❯

Citations

Nov 28, 2000·European Journal of Immunology·G R FosterG Lombardi
Dec 18, 2001·European Journal of Immunology·S RothenfusserG Hartmann
Dec 18, 2001·European Journal of Immunology·W ZouT J Curiel
Dec 14, 2004·European Journal of Immunology·Winfried BarchetMarco Colonna
Jan 13, 2001·Springer Seminars in Immunopathology·C CauxA Vicari
Aug 8, 2007·Archives of Dermatological Research·Sunit P Jariwala
Oct 10, 2006·Cancer Metastasis Reviews·Michael R ShurinRobert L Ferris
Dec 29, 2005·Journal of Clinical Immunology·Peter DubskyA Karolina Palucka
Jun 20, 2006·Journal of Clinical Immunology·Michelle A BarronCara C Wilson
Mar 3, 2009·Journal of Clinical Immunology·Leanne M Johnson-HuangMichelle A Lowes
Mar 7, 2009·Journal of Clinical Immunology·Wei Cao
Dec 21, 2007·Clinical Reviews in Allergy & Immunology·Andreas Wollenberg, Elisabeth Klein
Dec 25, 2010·Clinical Reviews in Allergy & Immunology·Andreas WollenbergJürgen Schauber
Jul 1, 2011·Immunologic Research·Elizabeth R WonderlichSimon M Barratt-Boyes
Oct 19, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Weiwei ShiShunchang Jiao
Mar 6, 2004·Seminars in Immunology·Michael Dee Gunn
Sep 11, 2001·The American Journal of Pathology·S A PileriP G Isaacson
Sep 21, 2000·Immunology Letters·M Nouri-ShiraziK Palucka
Oct 2, 2001·Immunology Letters·R Keller
Jan 5, 2011·Cellular & Molecular Immunology·Xi Yang, Xiaoling Gao
Mar 19, 2008·Immunology and Cell Biology·Frederick MassonGabrielle T Belz
Apr 17, 2008·Immunology and Cell Biology·Anita Sapoznikov, Steffen Jung
Apr 3, 2008·Immunology and Cell Biology·Sandra S Diebold
Jan 12, 2011·Immunology and Cell Biology·Joanna R Groom, Andrew D Luster
Sep 26, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·David L JayeDan Jones
Oct 21, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Phonphimon WongthidaRichard Vile
Apr 8, 2009·Nature Immunology·Sammy BedouiWilliam R Heath
Nov 20, 2012·Nature Immunology·Ansuman T SatpathyKenneth M Murphy
Sep 30, 2004·Nature Immunology·Akiko Iwasaki, Ruslan Medzhitov
Nov 19, 2004·Nature Immunology·Marco ColonnaYong-Jun Liu
Nov 29, 2001·Nature Immunology·D F Tough, A T Kamath
Aug 3, 2004·Nature Reviews. Immunology·Jukka Vakkila, Michael T Lotze
Feb 3, 2005·Nature Reviews. Immunology·Michael Lohoff, Tak W Mak
Apr 2, 2005·Nature Reviews. Immunology·Jacques Banchereau, A Karolina Palucka
Aug 20, 2005·Nature Reviews. Immunology·Thomas DeckerSilvia Stockinger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.