Plasmacytoid pre-dendritic cells (pDC): from molecular pathways to function and disease association

Seminars in Cell & Developmental Biology
Solana AlculumbreVassili Soumelis

Abstract

Plasmacytoid pre-dendritic cells (pDC) are a specialized DC population with a great potential to produce large amounts of type I interferon (IFN). pDC are involved in the initiation of antiviral immune responses through their interaction with innate and adaptive immune cell populations. In a context-dependent manner, pDC activation can induce their differentiation into mature DC able to induce both T cell activation or tolerance. In this review, we described pDC functions during immune responses and their implication in the clearance or pathogenicity of human diseases during infection, autoimmunity, allergy and cancer. We discuss recent advances in the field of pDC biology and their implication for future studies.

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Citations

Jan 24, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sabira MohammedKuzhuvelil B Harikumar
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Sep 4, 2020·Proceedings of the National Academy of Sciences of the United States of America·Chunmei FuAimin Jiang
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Apr 6, 2021·Current Opinion in Immunology·Nicolas Charles

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