Plasmacytoids dendritic cells are a therapeutic target in anticancer immunity

Biochimica Et Biophysica Acta
Giuseppe PalmaClaudio Arra

Abstract

Dendritic cells (DCs) are immunological sentinels of the organism acting as antigen-presenting cells (APC) and are critical for induction of innate and adaptive immunity. Traditionally they are divided in myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs), a rare population of circulating cells that selectively express Toll-like receptors (TLR) 7 and TLR9 and have the capacity to produce large amounts of type I interferons (IFNs) in response to pathogenic agents or danger signals. It has been demonstrated that pDCs can coordinate events during the course of viral infections, allergic and autoimmune diseases and cancer. Through the production of type I IFNs, pDCs initiate protective immunity by activating classical DCs, T cells, natural killer cells and B cells. Upon activation, pDCs also differentiate into mature DCs and may contribute to the contraction of T-cell response. Human pDCs preferentially express immunoglobulin-like transcript 7 (ILT7; LILRA4), which couples with a signaling adapter to activate a prominent immune-receptor tyrosine-based activation motif (ITAM)-mediated signaling pathway. The interaction between ILT7 and bone marrow stromal cell antigen 2 (BST2, CD317) assures an appropriate TLR re...Continue Reading

References

Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·B PulendranC R Maliszewski
Jul 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·S BauerG B Lipford
Sep 10, 2002·Dermatology : International Journal for Clinical and Investigative Dermatology·Anne B BongHarald Gollnick
Mar 8, 2003·Archives of Dermatology·Ingrid H WolfHelmut Kerl
Nov 18, 2003·The British Journal of Dermatology·R DummerG Burg
Feb 10, 2004·European Journal of Immunology·Laurence ChaperotJoël Plumas
Feb 21, 2004·Science·Sandra S DieboldCaetano Reis e Sousa
Mar 23, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jennifer M LundRichard A Flavell
Jun 23, 2004·Trends in Immunology·Hermann Wagner
Sep 24, 2004·British Journal of Plastic Surgery·David ChinWilliam B Coman
Sep 25, 2004·Journal of Cellular Physiology·Michele CaragliaAlberto Abbruzzese
Nov 18, 2004·Immunological Reviews·Sidney PestkaMark R Walter
Nov 19, 2004·Nature Immunology·Marco ColonnaYong-Jun Liu
Dec 8, 2004·Current Protein & Peptide Science·Michele CaragliaAlberto Abbruzzese
Nov 24, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M Naranjo-GómezF E Borràs
Aug 26, 2006·Nature Reviews. Immunology·Kenya Honda, Tadatsugu Taniguchi
May 24, 2007·The American Journal of Dermatopathology·Ingrid H WolfHelmut Kerl
Sep 26, 2007·Immunity·Marco Colonna, Marina Cella
Nov 30, 2007·Annual Review of Immunology·Gwendalyn J RandolphSantiago Partida-Sánchez
Jan 26, 2008·Blood·Teresa MarafiotiDavid Y Mason
Apr 22, 2008·Nature Immunology·Sudhir Pai Kasturi, Bali Pulendran
Jul 22, 2008·Nature Reviews. Immunology·Michel GillietYong-Jun Liu
Apr 23, 2009·The Biochemical Journal·Himanshu KumarShizuo Akira
Feb 1, 2011·American Journal of Respiratory and Critical Care Medicine·Rosalinda SorrentinoAldo Pinto

❮ Previous
Next ❯

Citations

Jul 16, 2013·The Veterinary Journal·Mark A Suckow
Aug 28, 2021·Journal of Clinical Medicine·Andrea KnightRoman Hajek

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.