Plasmalogens in rat liver chromatin: new molecules involved in cell proliferation

Journal of Cellular Physiology
Elisabetta AlbiC Sartori

Abstract

A minor component of chromatin, the phospholipid fraction, changes during cell cycle as result of the activation of intranuclear lipid metabolism enzymes including phosphatidylcholine-dependent phospholipase C activity. It is known that this enzyme may be activated by phosphatidylcholine plasmalogen (Plg). Until now, there has been little evidences for the presence of Plgs inside the nucleus. The aim of our study is to ascertain if they are present in the nucleus and are responsible of the activation of phosphatidylcholine-dependent phospholipase C during cell proliferation and apoptosis. Therefore, we have analysed the Plg composition of the whole homogenate, cytosol, nuclei and chromatin of hepatocytes. The phosphatidylcholine-dependent phospholipase C activity was assayed using both phosphatidylcholine and plasmalogenyl-phosphatidylcholine as substrates. Our results show, for the first time, that Plgs are present in chromatin and the plasmalogenyl-phosphatidylcholine stimulates the phosphatidylcholine-dependent phospholipase C activity more than phosphatidylcholine. Finally, in order to verify the possible role of these molecules during cell proliferation and apoptosis, we used liver of rats fed with ciprofibrate which stimu...Continue Reading

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Citations

Dec 30, 2011·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Tomoyuki NakanoKaoru Goto
Jul 5, 2011·Chemistry and Physics of Lipids·Stefan Wallner, Gerd Schmitz
Oct 18, 2008·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Marco Fidaleo
Apr 25, 2008·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Marco Fidaleo, Claudia Sartori
Jan 29, 2008·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Marco FidaleoClaudia Sartori
May 1, 2011·NMR in Biomedicine·Kamaiah JayalakshmiNeeraj Sinha
Aug 12, 2009·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Akhlaq A Farooqui

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