Plasmapheresis before thymectomy in myasthenia gravis: routine versus selective protocols

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Hatem El-BawabKhaled Al-Kattan

Abstract

The value of thymectomy in management of myasthenia gravis (MG) is well recognized. Plasmapheresis (PMP) before thymectomy appears to improve the postoperative outcome. As PMP has its own complications, selective use of PMP preoperatively for patients at risk of post-thymectomy complications would improve the postoperative outcome, and decreases the PMP-related complications. The aim of this study is to evaluate the effectiveness and safety of routine versus selective use of PMP before thymectomy. We performed a retrospective analysis of two different protocols in two institutions comparing the routine (group I) versus selective use (group II) of prethymectomy PMP. The computerized database and the medical records of 164 patients diagnosed with MG who underwent thymectomy between 1998 and 2007, were reviewed. In group I, 74 patients were treated with PMP before thymectomy. In group II (90 patients), 35 patients were identified as high-risk and were treated with PMP before thymectomy, and in 55 patients, thymectomy was performed without preoperative PMP. There was significant difference in the recorded PMP-related complications between group I and group II; 25.7% (19 patients) versus 8.9% (8 patients), respectively. There was no...Continue Reading

Citations

Jul 11, 2013·ISRN Neurology·Somcharoen SaetengYuttaphan Wannasopha
Oct 25, 2011·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Milan BlahaHana Langrova
Mar 16, 2011·Muscle & Nerve·Aditya MandawatAmer Alshekhlee
Nov 10, 2010·Annals of Neurology·Aditya MandawatAmer Alshekhlee
Jun 23, 2010·Journal of Clinical Apheresis·Zbigniew M SzczepiorkowskiUNKNOWN Apheresis Applications Committee of the American Society for Apheresis
Jun 21, 2016·Journal of Clinical Apheresis
Aug 1, 2019·Interactive Cardiovascular and Thoracic Surgery·Tarcisio A ReisAntônio Jose Maria Cataneo
Feb 23, 2021·Case Reports in Neurology·Yusak M T SiahaanVinson Hartoyo

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