PMID: 6401518Jan 15, 1983Paper

Plasmapheresis in the initial treatment of insulin-dependent diabetes mellitus in children

British Medical Journal
J LudvigssonA Lernmark

Abstract

Several factors indicate that autoimmune mechanisms may play a part in the aetiology of insulin-dependent diabetes mellitus. At the onset of the disease in 10 children (aged 11-16 years) plasmapheresis was performed four times over one to two weeks. Seventeen age-matched children with the same clinical features served as controls. The C-peptide concentrations at onset were the same in the two groups, but after one month the children treated with plasmapheresis had significantly higher values. This difference became even more pronounced after three, nine, and 18 months, both during fasting and at the maximum response to a standardised meal. The study group also had a significantly more stable metabolism, longer partial remission, and no higher insulin requirement. Of the 10 treated children islet-cell cytoplasmic antibodies were present in seven before plasmapheresis and in nine during treatment. The antibodies remained detectable in five and six out of nine patients at one and six months respectively after plasmapheresis. Although the mechanisms are obscure, plasmapheresis performed at the onset of insulin-dependent diabetes mellitus may help to preserve beta-cell function.

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Citations

Apr 18, 2001·Diabetes/metabolism Research and Reviews·J LudvigssonL Stenhammar
Nov 1, 1989·Indian Journal of Pediatrics·J Ludvigsson
Sep 15, 2004·Diabetologia·D LuoA Lernmark
Jul 30, 2010·Current Diabetes Reports·Johnny Ludvigsson, UNKNOWN Linköping Diabetes Immune Intervention study group
Sep 1, 1986·Current Problems in Pediatrics·A L Drash
Mar 2, 1985·Lancet·R D LeslieA M Denman
Nov 10, 1983·The New England Journal of Medicine·UNKNOWN Diabetes Research Program, National Institutes of Health
May 22, 1986·The New England Journal of Medicine·G S Eisenbarth
Oct 10, 2008·The New England Journal of Medicine·Johnny LudvigssonRosaura Casas
Feb 1, 1986·Archives of Disease in Childhood·M D HockingM Nattrass
Apr 1, 1986·Archives of Disease in Childhood·M D HockingM Nattrass
Jul 24, 2001·Archives of Disease in Childhood·J LudvigssonG Berlin
Jan 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·D I Slovick
Feb 1, 2011·Therapeutic Advances in Endocrinology and Metabolism·Tihamer Orban, Janos Tibor Kis
Jan 22, 2003·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·William E Winter, Desmond Schatz
Mar 15, 2011·Immunotherapy·Alba E Morales, Kathryn M Thrailkill
Jan 21, 1988·Journal of Immunological Methods·E BonifacioR L Dawkins
May 5, 2010·Acta Diabetologica·Douglas O SobelVal Abbassi
Dec 3, 2013·Expert Opinion on Pharmacotherapy·Johnny Ludvigsson
Mar 17, 2010·Expert Opinion on Biological Therapy·Johnny Ludvigsson
May 22, 2013·Medical Hypotheses·Mona Landin-OlssonCharlotte Erlanson-Albertsson
Mar 27, 2013·Diabetes Research and Clinical Practice·Johnny LudvigssonUlf Samuelsson
Dec 10, 2015·Drugs·Johnny Ludvigsson
Oct 31, 2009·Diabetes/metabolism Research and Reviews·Johnny Ludvigsson
Mar 10, 2009·Diabetes/metabolism Research and Reviews·Johnny Ludvigsson
Jul 10, 2008·Diabetes/metabolism Research and Reviews·Maria Nordwall, Johnny Ludvigsson
Apr 22, 2008·Clinical and Experimental Immunology·V A L HuurmanB O Roep
Dec 5, 2013·Diabetes/metabolism Research and Reviews·Johnny LudvigssonUNKNOWN Clinical GAD-Study Group in Sweden
Nov 1, 1985·Diabetic Medicine : a Journal of the British Diabetic Association·J NerupT Mandrup-Poulsen
Jan 1, 1986·Diabetes/metabolism Reviews·O K Faber, C Binder
Oct 1, 1987·Diabetes/metabolism Reviews·J S Skyler
Nov 1, 1988·Diabetic Medicine : a Journal of the British Diabetic Association·P Pozzilli
Apr 4, 2006·Trends in Endocrinology and Metabolism : TEM·Pablo A Silveira, Shane T Grey

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