Plasmapheresis in the treatment of posttransplant cardiomyopathy

Artificial Organs
S DzemeshkevichL Vinnitsky

Abstract

After heart transplantation a number of factors such as pre- and postoperative hypoxia of the myocardium, myocardial failure of the early postoperative period, acute rejection episodes, cytomegalovirus infection, and finally the progressive atherosclerosis of the coronary arteries lead to the development of transplanted heart failure. Severe alterations of the myocardial function at this end stage of the process correspond to incurable cardiomyopathy. The target of plasmapheresis in this case is to decrease the extent of the disturbances in the lipoprotein contents and blood rheology for the improvement of the coronary perfusion of the transplanted heart. Nine patients with 3-7 year survival periods after heart transplantations underwent plasmapheresis twice a year using the Haemonetics PCS-plus machine. 2,100-2,700 ml of plasma was removed. Biochemical data, rheology and coagulation, and the concentration of Sandimmune (Sandoz Pharma Ltd., Basel, Switzerland) were controlled, and radionuclide scintigraphy of the myocardium, coronarographia, and transesophageal ultrasound investigations were completed for these patients. The result was the significant improvement of the coronary perfusion of the myocardium. The level of immunos...Continue Reading

References

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Citations

Mar 21, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·O GrauhanR Hetzer
May 9, 2008·Journal of Cardiothoracic Surgery·Pavan AtluriY Joseph Woo
Apr 17, 2003·Journal of Cardiac Surgery·John V TerrovitisJohn N Nanas
Apr 12, 2014·Transfusion Medicine·O PignalosaC Napoli
May 5, 2010·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Rachel P SoslandPatrick M Moriarty

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