PMID: 8952855Jan 1, 1996Paper

Plasmatic parameters of coagulation activation in thrombotic microangiopathy

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
A SagripantiC Mittermayer

Abstract

Coagulation activation and fibrinolysis parameters were studied in eleven cases of thrombotic microangiopathy concerning eight adult patients. In addition to routine coagulation tests, antithrombin III, von Willebrand factor (vWF), prothrombin fragment 1+2 (F1+2), thrombin-antithrombin complex (TAT), D-dimer (DD), and plasminogen activator inhibitor type 1 (PAI-1) were measured in the plasma at the time of diagnosis and as soon as remission was achieved after therapy with plasma exchange and Iloprost. In the acute phase all patients showed normal aPTT, normal or slightly prolonged prothrombin time, normal or enhanced plasma levels of fibrinogen and antithrombin III, at variance with results in patients affected by disseminated intravascular coagulation. Mean F1+2, TAT, DD, vWF and PAI-1 were elevated in the acute phase, but decreased significantly in the early phase of remission. Our data provide evidence of increased thrombin generation rate which takes place in the acute phase of the disease and does not result in consumption coagulopathy, due to appropriate inhibition by antithrombin III; blood coagulation activation promptly decreased as soon as remission was achieved. Cross-linked fibrin deposition together with PAI-1 may ...Continue Reading

References

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Citations

Dec 2, 2000·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A SagripantiA Carpi
Feb 28, 2007·Hematology·Massimo Franchini
May 31, 2007·Journal of Clinical Periodontology·S BizzarroB G Loos
Feb 18, 2003·British Journal of Haematology·Sarah L AllfordUNKNOWN Haemostasis and Thrombosis Task Force, British Committee for Standards in Haematology
Nov 20, 1998·The American Journal of Gastroenterology·M VergaraJ R Malagelada
Nov 10, 2017·Scandinavian Journal of Clinical and Laboratory Investigation·Solbjørg SagedalPer Morten Sandset
Mar 12, 2013·Virchows Archiv : an International Journal of Pathology·Friedrich ModdeJan Ulrich Becker

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