PMID: 754520Jan 1, 1978Paper

Plasmid curing and antibacterial effects of some chlorpromazine derivatives in relation to their molecule orbitals

Acta Microbiologica Academiae Scientiarum Hungaricae
J Molnár, B Schneider

Abstract

7-Hydroxychlorpromazine, 7,8-dihydroxychlorpromazine and 7,8-dioxochlorpromazine exerted a bacteriostatic effect on Gram-positive and Gram-negative bacteria, with the latter being more resistant. The three compounds also had a bactericidal effect on selected strains of Escherichia coli and Staphylococcus aureus. 7-Hydroxychlorpromazine was able to cure 2% of F'lac plasmid of the E. coli K-12 LE 140 strain at 60 micrograms/ml, while 7,8-dihydroxychlorpromazine and its quinone failed to produced such an effect at the same concentration. In the presence of 0.1 M magnesium sulphate the plasmid curing effect of CPZ and 7-OH-CPZ decreased markedly, while the MIC values of CPZ and its derivatives increased. It seems therefore that the relative ineffectivity of CPZ in the presence of magnesium ions was not due to its metal chelation.

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Related Papers

Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology
R Egger, G Lebek
© 2021 Meta ULC. All rights reserved