PMID: 7983345Aug 1, 1994Paper

Plasmid DNA profiles of Acinetobacter baumannii: clinical application in a complex endemic setting

Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
H SeifertG Pulverer

Abstract

To study the epidemiological, microbiological, and clinical features of infections due to Acinetobacter baumannii in a complex endemic situation over an 18-month period and to determine the clinical usefulness of plasmid DNA analysis of A baumannii in epidemiological investigations. Review of medical and laboratory records. Antibiotic resistance patterns, biotyping, and plasmid profile analysis were used to characterize clinical and environmental isolates. Pulsed-field gel electrophoresis (PFGE) of chromosomal DNA was performed to verify results obtained with the other typing methods. Four different intensive care units of an 800-bed tertiary care center in Cologne, Germany. 240 patients were colonized or infected with A baumannii during the study period. No seasonal variations were observed. The majority of isolates (53%) were recovered from the respiratory tract. Major infections occurred in 61 patients; these included 48 bacteremias and eight pulmonary infections. Five different epidemic strains were identified: one each was A baumannii biotype 2 and 6, and three were biotype 9. A baumannii biotype 9 accounted for the vast majority of isolates (88%), which were clustered into three epidemic strains demonstrating distinct pla...Continue Reading

Citations

Oct 19, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Harald Seifert, Hilmar Wisplinghoff
Jul 29, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·V M ManikalJ Quale
Feb 1, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pierre Edouard Fournier, Hervé Richet
Jul 16, 2008·Clinical Microbiology Reviews·Anton Y PelegDavid L Paterson
Jul 25, 2012·Infection and Immunity·Leticia V BentancorTomás Maira-Litrán
Jan 7, 2005·Journal of Clinical Microbiology·Mimi HealyJames R Lupski
Mar 30, 2013·BMC Microbiology·Claire Valiente MoroPatrick Mavingui
Jan 18, 2006·PLoS Genetics·Pierre-Edouard FournierJean-Michel Claverie
Dec 17, 2008·Future Microbiology·Matteo BassettiLaura Nicolini
Oct 1, 1995·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·G SeltmannH Seifert
Sep 4, 2009·The Journal of Hospital Infection·S J Dancer
Nov 22, 2008·The Lancet Infectious Diseases·Drosos E Karageorgopoulos, M E Falagas

Related Concepts

Mima
Acinetobacter Infections
Infections, Hospital
Disease Outbreaks
DNA, Bacterial
Antibiotic Resistance, Microbial
Hospital Bed Capacity,500 and Over
Hospitals, University
Episomes
Streak Plate Count

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