Aug 19, 2003

Plasmid-mediated antimicrobial resistance in Salmonella enterica

Current Issues in Molecular Biology
Alessandra Carattoli

Abstract

The selective pressure imposed by the use of antimicrobials in both human and veterinary medicine promotes the spread of multiple antimicrobial resistance. The dissemination of antimicrobial resistance in Salmonella enterica strains, causing severe enteritis in human, has been reported worldwide and is largely attributed to conjugative DNA exchange. In the present review, the relevance of plasmids to the dissemination of antimicrobial resistance in S. enterica is discussed. Recent examples of plasmid-mediated resistance to expanded-spectrum cephalosporins are reported to illustrate the severity of current situation in enteric pathogens. The exchanges between plasmid(s) and the bacterial chromosome and the integration of resistance genes into specialised genetic elements, called integrons, play a major role in acquisition and dissemination of resistance genes. The evolution of a plasmid through the acquisition of integrons is reported, describing novel mechanisms for short-term accumulation of resistance determinants in plasmids circulating in Salmonella.

  • References39
  • Citations61

Mentioned in this Paper

Salmonella enterica
Integrons
Enteritis
Salmonella Infections
Drug Resistance, Multiple, Bacterial
Evolution, Molecular
Antibiotics
DNA Transposons
Antibiotic Resistance, Bacterial
Episomes

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Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

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