Plasmid-mediated quinolone resistance in human non-typhoidal Salmonella infections: An emerging public health problem in the United States

Zoonoses and Public Health
B E KarpCindy R Friedman

Abstract

Invasive Salmonella infections in adults are commonly treated with fluoroquinolones, a critically important antimicrobial class. Historically, quinolone resistance was the result of chromosomal mutations, but plasmid-mediated quinolone resistance (PMQR) has emerged and is increasingly being reported in Enterobacteriaceae worldwide. PMQR may facilitate the spread of quinolone resistance, lead to higher-level quinolone resistance, and make infections harder to treat. To better understand the epidemiology of PMQR in non-typhoidal Salmonella causing human infections in the United States, we looked at trends in quinolone resistance among isolates submitted to the Centers for Disease Control and Prevention. We reviewed demographic, exposure and outcome information for patients with isolates having a PMQR-associated phenotype during 2008-2014 and tested isolates for quinolone resistance mechanisms. We found that PMQR is emerging among non-typhoidal Salmonella causing human infections in the United States and that international travel, reptile and amphibian exposure, and food are likely sources of human infection.

References

Nov 1, 1995·The Pediatric Infectious Disease Journal·D M AckmanP Cieslak
Jan 25, 2003·Antimicrobial Agents and Chemotherapy·Frank Møller AarestrupE John Threlfall
Jun 28, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John A CrumpFrederick J Angulo
Apr 20, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jonathan MerminUNKNOWN Emerging Infections Program FoodNet Working Group
Apr 26, 2005·International Journal of Antimicrobial Agents·Katie L HopkinsE John Threlfall
May 5, 2005·Applied and Environmental Microbiology·Donna KilmartinM Cormican
Jan 5, 2006·Applied and Environmental Microbiology·María Alejandra DíazRonald John Siebeling
Jun 29, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kathryn GayDavid C Hooper
Sep 30, 2006·The Lancet Infectious Diseases·Ari RobicsekDavid C Hooper
Apr 17, 2007·The Journal of Antimicrobial Chemotherapy·Katie L HopkinsE John Threlfall
Aug 28, 2007·Applied and Environmental Microbiology·Ashraf M AhmedTadashi Shimamoto
Feb 9, 2008·Emerging Infectious Diseases·Katie L HopkinsE John Threlfall
Feb 19, 2009·Antimicrobial Agents and Chemotherapy·Maria Sjölund-KarlssonJean M Whichard
Sep 9, 2009·Foodborne Pathogens and Disease·Rene S HendriksenFrank M Aarestrup
Jul 6, 2010·The Journal of Antimicrobial Chemotherapy·Beatriz GuerraAndreas Schroeter
Oct 30, 2010·Emerging Infectious Diseases·Maria Sjölund-KarlssonPatrick F McDermott
May 14, 2011·Foodborne Pathogens and Disease·Laura R JohnsonUNKNOWN Foodnet Travel Working Group
Dec 30, 2011·Journal of Clinical Microbiology·Rene S HendriksenFrank M Aarestrup
May 18, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Magdalena E KendallBarbara E Mahon
Jul 4, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Romney M HumphriesJanet A Hindler
Jun 10, 2014·Zoonoses and Public Health·T WhittenJ Scheftel
Jun 29, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Allison T O'DonnellBeth E Karp
Jan 15, 2015·Microbiology Spectrum·George A JacobyDavid C Hooper
Jul 21, 2015·Annals of the New York Academy of Sciences·David C Hooper, George A Jacoby
Nov 28, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·B YanatA Touati
Dec 4, 2016·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·José Manuel Rodríguez-MartínezAlvaro Pascual
Nov 28, 2017·Microbial Genomics·Martin HuntSimon R Harris

❮ Previous
Next ❯

Citations

Sep 25, 2019·International Journal of Molecular Sciences·Liding ZhangJinyang Zhang
Feb 19, 2019·EFSA Journal·UNKNOWN EFSA Panel on Biological Hazards (EFSA BIOHAZ Panel)Robert Davies
Jan 21, 2021·Tropical Medicine and Infectious Disease·Hamid BokharyGrant A Hill-Cawthorne
May 21, 2021·Emerging Infectious Diseases·Felicita MedallaRobert M Hoekstra

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.