Plasmid Partitioning by Human Tumor Viruses

Journal of Virology
Ya-Fang Chiu, Bill Sugden

Abstract

The human tumor viruses that replicate as plasmids (we use the term plasmid to avoid any confusion in the term episome, which was coined to mean DNA elements that occur both extrachromosomally and as integrated forms during their life cycles, as does phage lambda) share many features in their DNA synthesis. We know less about their mechanisms of maintenance in proliferating cells, but these mechanisms must underlie their partitioning to daughter cells. One amazing implication of how these viruses are thought to maintain themselves is that while host chromosomes commit themselves to partitioning in mitosis, these tumor viruses would commit themselves to partitioning before mitosis and probably in S phase shortly after their synthesis.

References

Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J YatesB Sugden
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·K J AubornC L Schildkraut
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L YangM Botchan
Apr 17, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A N PlayerJ A Kolberg
Aug 23, 2001·Proceedings of the National Academy of Sciences of the United States of America·B ChaudhuriJ L Yates
Mar 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Brian A Van TineLouise T Chow
Apr 14, 2006·Journal of Virology·Ralf HoffmannKenneth Raj
Jul 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Chen-Yu Wang, Bill Sugden
Jul 16, 2013·Virology·Alison A McBride
Nov 28, 2013·PLoS Pathogens·Nozomi SakakibaraAlison A McBride
May 8, 2015·Proceedings of the National Academy of Sciences of the United States of America·Jan HellertThorsten Lührs

❮ Previous
Next ❯

Citations

Jul 10, 2019·Annual Review of Virology·Tami L Coursey, Alison A McBride
Apr 2, 2020·Seminars in Immunopathology·Alexander Buschle, Wolfgang Hammerschmidt
Oct 30, 2020·Frontiers in Cellular and Infection Microbiology·Katrin Mauch-MückeMichael M Nevels
Apr 11, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C BaileyC Swanton
Mar 3, 2021·Current Opinion in Virology·Eugene V KooninMart Krupovic
Mar 7, 2021·Viruses·Ashley N Della FeraAlison A McBride
Oct 19, 2019·Trends in Microbiology·Alessandra De LeoPaul M Lieberman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.