Plasmid pUDK-HGF encoding human hepatocyte growth factor gene attenuates gentamicin-induced kidney injury in rats

Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
Xing ChenQinglin Zhang

Abstract

The clinical application of gentamicin has been limited by its nephrotoxicity, which is characterized by kidney injury, interstitial fibrosis and progressive renal impairment. In this paper, we examine effects of plasmid pUDK-HGF which encodes the human hepatocyte growth factor (HGF) gene on gentamicin-induced renal injury in rats. The kidney injury was intentionally induced by injecting gentamicin intraperitoneally. On the third day after last gentamicin treatment, pUDK-HGF was injected into the left kidney tissue only once via a sterile back incision. At day 30 after gentamicin treatment, RI, Scr, BUN, 24 h-UTP and apoptotic cell death were determined. Tubulointerstitial injury and the renal interstitial vessel regeneration were evaluated by histological scoring. pUDK-HGF treatment significantly improved the renal function with decreasing RI, Scr and BUN. 24 h-UTP also presented ameliorating trend compared to the control group with kidney injury. pUDK-HGF treatment significantly decreased the score of tubulointerstitial injury and enhanced angiogenesis, also prevented kidney cells from apoptosis. The tubulointerstitial injury was significantly reduced in the pUDK-HGF injected left kidney and right kidney also showed some impr...Continue Reading

References

Sep 18, 2002·Kidney International·Xiaojie GaoTakakuni Tanizawa
Oct 24, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Toshiyuki TanakaHidetoshi Yamanaka
Mar 20, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Koji YazawaAkihiko Okuyama
May 20, 2004·Kidney International·Masayuki MizuiMasatsugu Hori
Oct 7, 2004·Journal of the American Society of Nephrology : JASN·Chunsun DaiYouhua Liu
Oct 4, 2005·Advances in Chronic Kidney Disease·Allison A Eddy
Jan 13, 2006·Kidney International·Youhua Liu
Jun 6, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R A VolpiniT M Coimbra
Jan 12, 2007·Journal of Applied Toxicology : JAT·Meltem KolgaziInci Alican
Mar 7, 2007·Gene Therapy·C M H Newman, T Bettinger
Jan 16, 2009·American Journal of Physiology. Renal Physiology·Tim D Hewitson
May 12, 2009·Biochemical and Biophysical Research Communications·Stephanie SchievenbuschMargarete Odenthal
Aug 20, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Su-Fang ShiHai-Yan Wang

❮ Previous
Next ❯

Citations

Oct 16, 2015·Journal of Receptor and Signal Transduction Research·Song Mao, Jianhua Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Grant BledsoeJulie Chao
Pharmacological Research : the Official Journal of the Italian Pharmacological Society
A AteşşahinI Princci
© 2021 Meta ULC. All rights reserved