PMID: 44236Dec 1, 1979

Plasmin can activate plasma prorenin but is not required for the alkaline phase of acid activation

Clinical Science
J E SealeyA P Kaplan


1. Plasma prorenin is an inactive form of renin that is converted into active renin at alkaline pH in previously acidified plasma; this conversion of prorenin into renin is mediated by Hageman factor-dependent activation of prekallikrein, which, in turn, leads to prorenin activation. 2. Since plasma kallikrein can activate plasminogen, the present studies were designed to evaluate whether alkaline-phase activation of prorenin by plasma kallikrein is mediated via plasminogen activation. 3. We demonstrated that plaminogen is present in acid-treated plasma in sufficient quantity to convert prorenin into renin after activation by streptokinase. 4. However, alkaline-phase activation was completely normal in plasminogen-free plasma. 5. Therefore alkaline-phase activation of plasma prorenin is mediated by plasma kallikrein but is not dependent on kallikrein activation of plasminogen.


Feb 7, 2013·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Jin Bo Su
Jan 1, 1995·Journal of Biomaterials Science. Polymer Edition·L Feng, J D Andrade

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