Plasmin in Parasitic Chronic Infections: Friend or Foe?

Trends in Parasitology
Javier González-MiguelFernando Simón

Abstract

Plasmin is the final product of the fibrinolytic system, the physiological mechanism responsible for dissolving fibrin clots. Its broad-range proteolytic activity implies that interaction with fibrinolysis and recruitment of plasmin by blood and tissue parasites is an important mechanism that mediates the invasion and establishment of this kind of pathogen in the hosts. However, recent studies have linked an excess of plasmin generated by this interaction with serious pathological events at the vascular level, including the proliferation and migration of arterial wall cells, inflammation, and degradation of the extracellular matrix. Therefore, we present data that support the need to reconsider the role of plasmin, as well as its benefits or drawbacks, in the context of host-parasite relations.

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Citations

Aug 4, 2016·Molecular and Biochemical Parasitology·Eduardo de la Torre-EscuderoAna Oleaga
Sep 1, 2018·Bioscience Reports·Dolores A Ayón-NúñezJuan P Laclette
Jun 17, 2020·Journal of Thrombosis and Haemostasis : JTH·Robert L MedcalfPaul S Myles
Nov 5, 2019·Frontiers in Genetics·Sandra Grossi GavaMarina Moraes Mourão
Jun 24, 2017·BioMed Research International·Fernando SimónVladimir Kartashev
Apr 27, 2017·Frontiers in Microbiology·Xiangye LiuKuiyang Zheng
Oct 18, 2020·Trends in Parasitology·Javier González-MiguelMar Siles-Lucas
Feb 7, 2021·Science Advances·Thiago Luiz Alves E SilvaJoel Vega-Rodríguez
Nov 20, 2021·Frontiers in Cellular and Infection Microbiology·Nina Gillis-GermitschManuela Schnyder

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