Abstract
Plasminogen activators provide effective treatment for patients with acute myocardial infarction. However, paradoxical elevation of thrombin activity associated with failure of clot lysis and recurrent thrombosis has been reported. Generation of thrombin in these circumstances appears to be owing to plasmin (Plm)-induced activation of factor (F) XII. Plm catalyzes proteolysis of several coagulant factors, but the roles of these factors on Plm-mediated procoagulant activity remain to be determined. Recently developed global coagulation assays were used in this investigation. Rotational thromboelastometry using whole blood, clot waveform analysis and thrombin generation tests using plasma, showed that Plm (> or =125 nmol/l) shortened the clotting times in similar dose-dependent manners. In particular, the thrombin generation test, which was unaffected by products of fibrinolysis, revealed the enhanced coagulation with an approximately two-fold increase of peak level of thrombin generation. Studies using alpha2-antiplasmin-deficient plasma revealed that much lower dose of Plm (> or =16 nmol/l) actually contributed to enhancing thrombin generation. The shortening of clotting time could be observed even in the presence of corn tryps...Continue Reading
References
Apr 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J H Griffin
Mar 1, 1991·Circulation·D C GulbaP R Lichtlen
May 1, 1989·Circulation·H J RapoldA Haeberli
Sep 1, 1987·Journal of the American College of Cardiology·P R EisenbergA S Jaffe
Dec 1, 1974·Thrombosis Research·K Laake, B Osterud
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·W R ChurchD N Fass
Feb 17, 1981·Biochemistry·L T MimmsJ A Reynolds
Jan 1, 1995·Circulation·G A Ewald, P R Eisenberg
Dec 8, 1998·Circulation·H M HoffmeisterL Seipel
Mar 20, 1999·The Journal of Biological Chemistry·E L PryzdialG E Kessler
Jul 11, 2003·Pathophysiology of Haemostasis and Thrombosis·H Coenraad HemkerSuzette Béguin
Jan 14, 2004·Journal of Thrombosis and Haemostasis : JTH·M P LatachaD R Abendschein
Mar 24, 2005·Clinical and Laboratory Haematology·R J Luddington
Jan 20, 2006·Journal of Thrombosis and Haemostasis : JTH·T MatsumotoA Yoshioka
Dec 26, 2006·The Journal of Biological Chemistry·Keiji NogamiAkira Yoshioka
Mar 11, 2008·Biochimica Et Biophysica Acta·Keiji NogamiMidori Shima
Jun 25, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·M ShimaK Ogiwara
Jan 8, 2009·The Journal of Biological Chemistry·Keiji NogamiMidori Shima
Apr 8, 2009·Thrombosis and Haemostasis·Marie-Geneviève HuissePhilippe Gabriel Steg
Citations
Mar 8, 2013·Thrombosis and Haemostasis·Koji YadaMidori Shima
Jul 4, 2012·Critical Care : the Official Journal of the Critical Care Forum·Anne GodierBeverley J Hunt
Apr 9, 2014·BMC Veterinary Research·Lorenzo Enrique Hernández-CastellanoAnastasio Argüello
Jan 28, 2016·Journal of Thrombosis and Thrombolysis·Wu ChenLaiyou Wang
Mar 12, 2016·The Journal of Craniofacial Surgery·George Richard Francis MurphyAbhilash Jain
Dec 21, 2011·Hematology·Mark van GeffenWaander L van Heerde
Nov 21, 2013·Current Opinion in Structural Biology·Ruby H P LawJames C Whisstock
Aug 21, 2013·Critical Reviews in Oncology/hematology·Lutfi SuleimanHabib Boukerche
Jul 23, 2016·Journal of Clinical Pathology·Anne GodierBeverley J Hunt
Jan 17, 2017·Wellcome Open Research·Kastriot DallakuUlrich Mansmann
Sep 7, 2017·International Journal of Laboratory Hematology·P O Sevenet, F Depasse
Sep 1, 2018·Bioscience Reports·Dolores A Ayón-NúñezJuan P Laclette
Sep 30, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Kong-Nan ZhaoMartin F Lavin
Nov 28, 2012·Experimental and Therapeutic Medicine·Katarzyna OszajcaJanusz Szemraj
Nov 2, 2019·Journal of Thrombosis and Haemostasis : JTH·Małgorzata A PrzeradzkaAlexander B Meijer
Jul 17, 2019·Journal of Orthopaedic Surgery and Research·Xiang-Dong WuWei Huang
Jul 24, 2020·Journal of Thrombosis and Haemostasis : JTH·Magdalena Gierula, Josefin Ahnström
Apr 22, 2015·Bioorganicheskaia khimiia·R B Aĭsina, L I Mukhametova
Jun 22, 2019·Wellcome Open Research·Kastriot DallakuUlrich Mansmann
Jan 12, 2019·Biomedit︠s︡inskai︠a︡ khimii︠a︡·E V KugaevskayaN I Solovyeva
Mar 7, 2019·Biochemical Society Transactions·Guojie WuRuby H P Law
Oct 25, 2020·Journal of Thrombosis and Thrombolysis·Bingwen Eugene FanYew Woon Chia
Apr 4, 2021·International Journal of Molecular Sciences·Adam MisztaBas de Laat