Plasmin therapy enhances mobilization of HPCs after G-CSF.

Blood
Marc TjwaPeter Carmeliet

Abstract

The role of proteinases in the mobilization of hematopoietic progenitor cells (HPCs) after granulocyte colony-stimulating factor (G-CSF) remains unclear. Here we report that genetic loss of the plasminogen activator inhibitor Pai-1 or of the plasmin inhibitor alpha2-antiplasmin increases HPC mobilization in response to G-CSF. Moreover, thrombolytic agents, such as tenecteplase and microplasmin, enhance HPC mobilization in mice and humans. Taken together, these findings identify a novel role for plasmin in augmenting HPC mobilization in response to G-CSF.

References

Sep 15, 1994·European Journal of Biochemistry·H R LijnenD Collen
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·B A KeytJ Ogez
Nov 1, 1996·European Journal of Biochemistry·H R LijnenD Collen
Apr 16, 2002·Current Opinion in Hematology·John ThomasDaniel C Link
Nov 25, 2003·Hematology·Michele H Cottler-FoxSteven Devine
Mar 30, 2005·The Journal of Experimental Medicine·Ingrid G WinklerJean-Pierre Lévesque
Aug 7, 2007·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·F GrundmannJ Müller-Ehmsen
Mar 29, 2008·Cell Stem Cell·Beate HeissigKoichi Hattori

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Citations

Nov 3, 2012·Journal of Biomedicine & Biotechnology·Yanqing Gong, Jane Hoover-Plow
Apr 13, 2012·Biochemistry Research International·Neeta ShirvaikarAnna Janowska-Wieczorek
Sep 17, 2011·Pathology·L Bik ToIan D Lewis
Oct 4, 2011·Progress in Histochemistry and Cytochemistry·Claudia MerkwitzAlbert M Ricken
Nov 22, 2015·Advanced Drug Delivery Reviews·Beate HeissigKoichi Hattori
Apr 11, 2012·Transfusion·Anna Janowska-WieczorekMariusz Z Ratajczak
Jun 16, 2015·Frontiers in Immunology·Margot Zöller
Aug 13, 2011·Blood·L Bik ToKirsten E Herbert
Nov 9, 2016·International Journal of Hematology·Linda Bendall
Jan 24, 2017·Journal of Cellular Biochemistry·Mélanie J DominguesSusan K Nilsson
Sep 14, 2018·Frontiers in Cell and Developmental Biology·Zhe WangMargot Zöller
Feb 7, 2020·F1000Research·Darja KarpovaJohn F DiPersio

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