PMID: 8950585Nov 1, 1996Paper

Plasminogen activation in epiretinal membranes

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
I ImmonenV Sirén

Abstract

Formation of epiretinal membranes occurs in proliferative vitreoretinopathy, macular pucker and after penetrating trauma. Epiretinal membrane formation includes cell migration and proliferation, extracellular matrix formation and tissue contraction. Generally in scar tissue formation, the production of new extracellular matrix occurs concomitantly with its proteolytic degradation, resulting in continuous tissue remodelling. The plasminogen activator-mediated proteolytic cascade is an important mechanism for pericellular degradation of the extracellular matrix. Therefore we wanted to study the presence of the plasminogen activator-mediated proteolytic cascade in epiretinal membranes. Specimens of 18 epiretinal and 3 subretinal membranes were obtained during vitreous surgery for retinal detachment with proliferative vitreoretinopathy or macular pucker. Plasminogen activators and plasmin were characterized in frozen sections of epiretinal membranes by in situ zymography and in membrane lysates by zymography. Indirect immunofluorescence staining was performed to localize urokinase in epiretinal membranes. Urokinase was present in 17/21 and tissue-type plasminogen activator in 12/21 of the membranes studied. Active plasmin was not d...Continue Reading

Citations

Apr 11, 2003·Journal of Cataract and Refractive Surgery·Nick GeorgiadisVagia Moschou
Feb 5, 1999·Progress in Retinal and Eye Research·P HiscottI Grierson
Jul 16, 2011·The Kaohsiung Journal of Medical Sciences·Po-Yen LeeWen-Chuan Wu
Apr 13, 2011·Histopathology·Michaela KritzenbergerJost Hillenkamp
Jul 21, 2014·International Ophthalmology·Vasileios KonidarisPeriklis Brazitikos
Jul 12, 2014·Molecular BioSystems·Jing YuChunlei Xie
Oct 17, 2003·Current Eye Research·Vappu Sirén, Ilkka Immonen
Mar 16, 2021·European Journal of Ophthalmology·Perach OsaadonBoris Knyazer
Jul 16, 2019·Experimental Eye Research·Christos ChristakopoulosBent Honoré

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