PMID: 6169657Feb 15, 1981Paper

Plasminogen activator content of neoplastic and benign human prostate tissues; fibrin augmentation of an activator activity

International Journal of Cancer. Journal International Du Cancer
S M CamioloJ P Grimaldi

Abstract

The plasminogen activator content of the extracts of excise prostate cancers (25 specimens) was determined with an azocasein assay and found to be on the average 1.7 times higher than that of extracts of excised prostate benign hyperplasias (29 specimens). Both groups contained the same average percentage of human urokinase type activator (approximately 45%) as determined by the inhibition of activity when anti-human urokinase antibody was included in the assay system. The two types of activators were partially purified and found to have distinctly different properties. The most striking difference was the large augmentation of activity o the non-urokinase enzyme in fibrinolysis. The implications of an enhanced fibrinolysis relative to azocaseinolysis (or other) is discussed, particularly with respect to its importance in the quantitation and characterization of activators by different investigators. Highly purified urokinase-like activator was found to be similar to commercial urokinase preparation with respect to molecular weight, isoelectric point, inhibition by the antibody, and inhibition by placenta inhibitor.

References

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Citations

Jan 1, 1985·Clinical & Experimental Metastasis·R NgJ A Kellen
Mar 1, 1989·European Journal of Cancer & Clinical Oncology·H W VerspagetC B Lamers
May 2, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Abdul Waheed, Robert L Van Etten
Jan 1, 1996·Pathology, Research and Practice·C Ts'aoJ M Taylor
Jan 1, 1982·Preparative Biochemistry·S M CamioloJ M Madeja
Aug 1, 1994·British Journal of Urology·A S AdamsonM E Snell
Dec 29, 2005·International Journal of Cancer. Journal International Du Cancer·Venkata SabbisettiGirish Shah
Sep 1, 1985·Gynecologic Oncology·C W WhitneyR Mortel
Mar 1, 1987·Gynecologic Oncology·S M CamioloM S Piver
Oct 15, 1988·International Journal of Cancer. Journal International Du Cancer·P S SimW F Doe
Oct 15, 1988·International Journal of Cancer. Journal International Du Cancer·J SuzumiyaE Ishikawa
May 1, 1987·British Journal of Haematology·J C KirchheimerB R Binder
Sep 15, 1984·International Journal of Cancer. Journal International Du Cancer·J D TissotF Bachmann
Dec 1, 1988·European Journal of Clinical Investigation·K HuberB R Binder
Nov 1, 1987·Thrombosis Research·J C KirchheimerB R Binder
Mar 20, 2010·Surgical and Radiologic Anatomy : SRA·Elizabeth O JohnsonPanayotis N Soucacos
Nov 25, 1987·Biochimica Et Biophysica Acta·K TryggvasonT Salo
Dec 29, 1983·Biochimica Et Biophysica Acta·D E Mullins, S T Rohrlich
Mar 1, 1992·The Journal of Investigative Dermatology·S J MillerG S Lazarus

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