Abstract
Obesity promotes a low-grade systemic inflammatory state that may act on the lung to exacerbate asthma. There is little information on the relationship between systemic inflammation and lung function in children and adolescents. To explore the relationship among fibrinogen, plasminogen activator inhibitor-1 (PAI-1), lung function in adolescents with the presence of asthma, and/or obesity. Totally 178 adolescents (boys and girls) were involved; four groups were divided according to their diagnosis: non-obese and non-asthmatic controls (n = 38), non-obese asthmatics (n = 31), obese non-asthmatics (n = 62), obese asthmatics (n = 47). The levels of PAI-1 and fibrinogen were determined in blood samples. The lung function was evaluated with spirometry by measuring forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), and forced expiratory flows between 25 and75% (FEF(25-75%)). Compared to healthy controls, obese adolescents with or without asthma show higher levels of fibrinogen (289.2 ± 61.5, 328.4 ± 54.9, and 324.9 ± 68.9 mg/dL, respectively), PAI-1 (36.0 ± 17.3, 53.2 ± 22.3, and 52.6 ± 24.7 ng/mL, respectively), and the reduced FEV1/FVC ratio (87.7 ± 7.7, 81.6 ± 8.6, and 81.7 ± 6.9, respectively). In the whole studi...Continue Reading
References
Jul 1, 1991·Diabetologia·I Juhan-VagueP Vague
Mar 1, 1991·Circulation·J W YarnellP C Elwood
Apr 1, 1988·American Heart Journal·R B FrancisD I Feinstein
Sep 4, 1987·JAMA : the Journal of the American Medical Association·W B KannelR B D'Agostino
Mar 9, 1995·The New England Journal of Medicine·S G ThompsonJ C van de Loo
Jan 1, 1993·Diabetes·D J SchneiderB E Sobel
Jun 15, 1993·Annals of Internal Medicine·E Ernst, K L Resch
Jan 1, 1996·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·P L EnrightE C Lasser
May 26, 1998·JAMA : the Journal of the American Medical Association·J DaneshR Peto
Jan 7, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·V Mohamed-AliS W Coppack
Dec 11, 1999·JAMA : the Journal of the American Medical Association·M VisserT B Harris
May 12, 2000·JAMA : the Journal of the American Medical Association·E L KanabrockiJ H Olwin
Jun 1, 2000·Metabolism: Clinical and Experimental·M ValleR Cañete
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S H ChoC K Oh
Feb 27, 2001·Atherosclerosis·G EngströmL Janzon
Jul 20, 2001·Thorax·M M HabyS R Leeder
Oct 6, 2001·American Journal of Respiratory and Critical Care Medicine·M DahlB G Nordestgaard
Dec 26, 2001·American Journal of Respiratory and Critical Care Medicine·M ZureikP Ducimetière
Oct 24, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Pekka JousilahtiTimo Palosuo
Nov 13, 2002·Circulation·G EngströmF Lindgärde
Mar 26, 2003·Circulation·Don D Sin, S F Paul Man
Jun 24, 2003·Atherosclerosis·Barbara GlowinskaMarzena Galar
Jun 28, 2003·The American Journal of Medicine·David M ManninoStephen C Redd
Feb 12, 2005·Chest·Wen Qi GanDon D Sin
Oct 21, 2005·Chest·Wei XiaoRichard B Moss
Jan 18, 2006·Allergy·A PampuchL Iacoviello
Mar 24, 2006·International Journal of Epidemiology·Bharat ThyagarajanO Dale Williams
Oct 13, 2006·Obesity·Wen-Yuan LinKuo-Chin Huang
Apr 14, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P M MatricardiS Lau
Apr 21, 2007·The Journal of Allergy and Clinical Immunology·Hai Lee ChungSang Gyung Kim
May 30, 2008·Journal of Thrombosis and Haemostasis : JTH·P BalagopalD E Vaughan
Jul 22, 2008·Chest·Andréa LessardLouis-Philippe Boulet
Dec 10, 2008·Allergy and Asthma Proceedings·Ozlem Yilmaz OzbekNamik Ozbek
Feb 12, 2009·Pediatric Pulmonology·Diogenis SpathopoulosAthanasios Chatzimichael
May 15, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Z MaC K Oh
Sep 22, 2009·Pediatric Pulmonology·Qi-qiang HeIgnatius Tak-sun Yu
Sep 17, 2010·Proceedings of the American Thoracic Society·Anne E DixonUNKNOWN American Thoracic Society Ad Hoc Subcommittee on Obesity and Lung Disease
Citations
Jun 15, 2014·The Journal of Endocrinology·Ynuk Bossé
Feb 20, 2013·Equine Veterinary Journal·H WrayN J Menzies-Gow
May 26, 2017·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M G SherenianR Kumar
May 29, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R S KellyA C Wu
Jul 18, 2014·Endocrine Journal·Fengyang HuangEnrique Hong
Feb 23, 2019·Allergologia et immunopathologia·Manlio MilaneseDiego G Peroni
Jul 30, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Li HuangYungling L Lee