Plasminogen activator inhibitor 1 gene polymorphism and gestational diabetes mellitus

Obstetrics and Gynecology
Heinz LeipoldChristof Worda

Abstract

Plasminogen activator inhibitor 1 is thought to play a role in the pathogenesis of obesity and insulin resistance. Therefore, we examined a single nucleotide exchange in this gene in women with gestational diabetes mellitus. A total of 887 unselected women were prospectively screened for gestational diabetes mellitus by oral glucose testing between the 24th and 28th weeks of gestation. Eighty white women of this collective, 40 patients with a pathological oral glucose tolerance test and 40 normal control subjects, were randomly selected. DNA samples were isolated from the sera and analyzed for the functional -675 4G/5G promotor polymorphisms of the plasminogen activator inhibitor 1 gene. Women with gestational diabetes mellitus were significantly older and had a significantly higher body mass index (BMI) than those who did not have gestational diabetes mellitus. Women with normal glucose tolerance were significantly more often homozygous for the 5G allele (P = .01), independently of maternal age or BMI. Low fasting glucose values in the oral glucose tolerance test were significantly related to homozygosity for 5G (P = .02). Homozygosity for the 5G allele of the plasminogen activator inhibitor 1 gene is associated with normal gl...Continue Reading

References

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Jun 3, 2004·Obstetrics and Gynecology·Heinz LeipoldChristof Worda
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Citations

Apr 17, 2008·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Julie Robitaille, Althea M Grant
Nov 13, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Horng-Rong ChangJong-Da Lian
Apr 20, 2010·American Journal of Obstetrics and Gynecology·Aaron B CaugheyGabriel J Escobar
Aug 2, 2017·International Journal of Molecular Sciences·Yao YeViktoria von Schönfeldt
Jan 2, 2018·World Journal of Diabetes·AbdelHameed Mirghani Dirar, John Doupis
May 22, 2010·The British Journal of Nutrition·Clive J Petry
Jan 20, 2012·Molecular and Cellular Biochemistry·Karla S Fernandes, Valéria C Sandrim
Apr 25, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Katharina KleinChristof Worda
Aug 28, 2018·BioResearch Open Access·Deirdre Cocks EschlerCarol J Levy

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