Plasminogen activator inhibitor-1 in cancer research

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Sijing LiLi Sun

Abstract

[Despite as a major inhibitor of urokinase (uPA), paradoxically,] Plasminogen activator inhibitor-1 (PAI-1) has been validated to be highly expressed in various types of tumor biopsy tissues or plasma compared with controls based on huge clinical data bases analysis, more importantly, PAI-1 alone or in conjunction with uPA have been identified as prognostic for disease progression and relapse in certain cancer types. particularly in breast cancer. In addition to play important roles in cell adhesion, migration and invasion, PAI-1 has been reported to induce tumor vascularization and thus promote cell dissemination and tumor metastasis. Furthermore, there are many tumor promoting factors involved in the modulation of PAI-1 expression and activity, which will strengthen the pro-tumorigenic roles of PAI-1. Undoubtedly, PAI-1 may be a promising target for therapeutic intervention of specific cancer treatment. In fact, some PAI-1 inhibitors are currently being evaluated in cancer therapy, which may be developed to new antitumor agents in the future.

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Citations

Dec 19, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·E F Vasilyeva, O S Brusov
May 30, 2020·International Journal of Oncology·Daniel L PouliquenCatherine Guette
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Oct 1, 2020·International Journal of Molecular Sciences·Fasih Ahmad Rahman, Matthew Paul Krause
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Dec 4, 2021·Frontiers in Cell and Developmental Biology·Shaoshan Mai, Iwona Inkielewicz-Stepniak

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