Plasminogen Activator Inhibitor-1 Level Correlates with Lipoprotein Subfractions in Obese Nondiabetic Subjects

International Journal of Endocrinology
Sándor SomodiGyörgy Paragh

Abstract

The elevated level of plasminogen activator inhibitor-1 (PAI-1) in obese subjects with metabolic syndrome and in patients with type 2 diabetes is well established. The association of plasma PAI-1 and lipid metabolism is still unclear. The aim of the present study was to determine the relationship between plasma PAI-1 levels and the distribution of lipoprotein subfractions in obese and lean nondiabetic individuals. We enrolled fifty nondiabetic obese patients and thirty-two healthy volunteers. Lipoprotein subfractions were detected with Lipoprint System. Plasma PAI-1, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and myeloperoxidase (MPO) concentrations were determined with enzyme-linked immunosorbent assay (ELISA), while serum paraoxonase-1 (PON1) activities were measured by spectrophotometry. The TNF-α, IL-6, oxidized low-density lipoprotein (oxLDL), and MPO levels were found to be significantly higher, while PON1 paraoxonase and arylesterase activities were nonsignificantly lower in the obese patients. Strong significant negative correlations were found between plasma PAI-1 concentration and mean LDL size, as well as between PAI-1 concentrations and the levels of the large and intermediate high-density lipoprotein (H...Continue Reading

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Citations

Feb 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Laura KriegKristin Schubert
Oct 27, 2020·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Jitender Mohan KhungerMonica Khunger Malhotra
Apr 4, 2021·International Journal of Molecular Sciences·Machteld Sillen, Paul J Declerck
May 1, 2021·Nutrients·Maciej ZiętekMałgorzata Szczuko

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
electrophoresis
ELISA

Software Mentioned

Lipoware
Lipoprint
STATISTICA

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