Plasminogen activator inhibitor-1 predicts coronary in-stent restenosis of drug-eluting stents

Journal of Thrombosis and Haemostasis : JTH
K M KatsarosGünter Christ

Abstract

We tested the hypothesis that plasma levels of plasminogen activator inhibitor-1 (PAI-1) are influenced by percutaneous coronary intervention (PCI) with the implantation of drug eluting stents (DES) and are able to predict the occurrence of in-stent restenosis (ISR). PAI-1 active antigen plasma levels were determined in 75 patients before and 24 h after PCI with DES implantation. Patients with ISR after six to eight months (16%) showed significantly lower PAI-1 plasma levels before PCI (ISR, 11.7 +/- 8.1 ng mL(-1); non-ISR, 22.8 +/- 18.8 ng mL(-1); P <0.05). PAI-1 levels in the lowest tertile were associated with a 9.5-fold increased risk of ISR, independent of clinical risk factors, angiographic or procedural characteristics, compared to the highest tertile (P < 0.05). The induced change of PAI-1 active antigen 24 h after PCI was significantly higher in patients with ISR (ISR, +5.6 +/- 8.0 ng mL(-1); non-ISR, -3.2 +/- 12.1 ng mL(-1); P < 0.05) with positive correlation to late lumen loss (r = 0.30; P < 0.05). ISR after DES implantation is significantly related to plasma levels of PAI-1 active antigen before and after PCI. If confirmed by larger multicenter studies, the determination of PAI-1 plasma levels might be clinically h...Continue Reading

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Citations

Oct 31, 2013·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Katharina M KatsarosWalter S Speidl
Jan 5, 2011·Expert Opinion on Investigational Drugs·Jun-Ichi SuzukiRyozo Nagai
Nov 20, 2010·Journal of the American College of Cardiology·Giampaolo NiccoliFilippo Crea
Sep 14, 2011·Nature Reviews. Cardiology·J Wouter JukemaPaul H A Quax
Dec 3, 2015·Journal of Cardiovascular Medicine·Francesco FracassiEmanuele Barbato
May 9, 2019·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Richard G JungBenjamin Hibbert
Nov 23, 2020·Cardiovascular Intervention and Therapeutics·Jiro Aoki, Kengo Tanabe
Mar 2, 2018·Thrombosis Research·Richard G JungBenjamin Hibbert

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