Plasminogen activator inhibitor-1

Current Medicinal Chemistry
Ann Gils, Paul J Declerck

Abstract

Plasminogen activator inhibitor-1 (PAI-1) is an important component of the plasminogen/plasmin system as it is the main inhibitor of tissue-type and urokinase-type plasminogen activator. Consequently, PAI-1 plays an important role in cardiovascular diseases (mainly through inhibition of t-PA) and in cell migration and tumor development (mainly through inhibition of u-PA). As a member of the serpin superfamily, PAI-1 shares important structural properties with other serpins. However, PAI-1 also exhibits unique conformational and functional properties. The current paper provides an overview of the knowledge on PAI-1 gathered since its discovery two decades ago. We are discussing (a) its structural properties and their subsequent association with the functional properties, (b) its role in a wide variety of (patho)physiological processes and (c) a number of strategies to interfere with its functional properties eventually aiming at pharmacological modulation of this risk factor.

Citations

Sep 28, 2007·Rheumatology International·Nora Magdalena Torres-CarrilloJosé Francisco Muñoz-Valle
Jun 23, 2010·Clinical and Experimental Medicine·Jorge Ramón Padilla-GutiérrezJosé Francisco Muñoz-Valle
Jun 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·J Steven JacobsenMenelas N Pangalos
Apr 24, 2009·Tissue Engineering. Part a·Shohta KodamaCharles A Vacanti
Mar 6, 2012·Thyroid : Official Journal of the American Thyroid Association·Bernadett UjhelyiEndre V Nagy
Jun 13, 2014·Nucleic Acid Therapeutics·Jared DamareYolanda M Fortenberry
Jun 15, 2007·Protein Science : a Publication of the Protein Society·Aiwu Zhou
Dec 15, 2010·Journal of Thrombosis and Haemostasis : JTH·P SenL Vijaya Mohan Rao
Dec 1, 2005·Differentiation; Research in Biological Diversity·Angèle NalbandianDaniel Djakiew
Mar 26, 2013·Expert Opinion on Therapeutic Patents·Yolanda M Fortenberry
Feb 9, 2012·Biochimica Et Biophysica Acta·Sohee PharkDonggeun Sul
Apr 23, 2014·European Journal of Nutrition·Ngoc Minh PhamTetsuya Mizoue
Mar 22, 2013·Diabetes Care·Maria F Lopes-VirellaUNKNOWN DCCT/EDIC Research Group
May 4, 2017·American Journal of Alzheimer's Disease and Other Dementias·Najiba Fekih-MrissaBrahim Nsiri
Nov 3, 2016·American Journal of Physiology. Renal Physiology·Chunyan GuYufeng Huang
Jul 28, 2010·Therapeutic Advances in Cardiovascular Disease·Nancy J Brown
May 19, 2017·Journal of Cellular Biochemistry·Reyhaneh RabieianHamed Mirzaei
Jan 4, 2008·Hypertension·Nancy J Brown
Oct 13, 2006·Journal of the American Society of Nephrology : JASN·Allison A Eddy, Agnes B Fogo
Jun 21, 2019·Journal of Thrombosis and Haemostasis : JTH·Aditya GirishAnirban Sen Gupta
Nov 12, 2019·Cardiovascular Research·Melanie Ricke-HochDenise Hilfiker-Kleiner
Sep 2, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Galina FlorovaAndrey A Komissarov
Sep 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nelli ShushakovaInna Dumler
Aug 9, 2007·Clinical Science·Annis M Marney, Nancy J Brown
Mar 2, 2018·Thrombosis Research·Richard G JungBenjamin Hibbert

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