Plasminogen activator inhibitor and the risk of cardiovascular disease: The Framingham Heart Study

Thrombosis Research
G H ToflerRalph B D'Agostino

Abstract

Although plasminogen activator inhibitor (PAI-1) plays a key regulatory role in fibrinolysis, it has not been clearly shown to independently predict cardiovascular disease (CVD) among individuals without prior CVD. We investigated, in the Framingham Heart Study offspring cohort, whether PAI-1 predicted CVD risk among individuals without prior CVD. Plasma PAI-1 antigen and tissue plasminogen activator (TPA) antigen were measured in 3203 subjects without prior CVD between 1991 and 1995; average follow-up of 10 years. PAI-1 was remeasured 4 years after baseline, to determine the effect of serial change on risk. PAI-1 levels (mean ± SD) were 29.1 ng/ml (19.2) versus 22.1 (16.5) for those and without incident CVD; p<0.001, and TPA levels were 12.0 ng/ml (5.7) versus 9.0 (4.7); p<0.001. PAI-1 and TPA antigen levels had a strong unadjusted linear relation with incident CVD (p<0.001). After adjustment for conventional risk factors, the hazard ratios (HRs) for higher quartiles of PAI-1, compared with the lowest, were 1.9, 1.9, 2.6 (linear trend p=0.006), and 1.6, 1.6, 2.9 (p<0.001) for TPA antigen. The adjusted HRs for increasing quartiles of serial change in PAI-1 at 4 years, compared with the lowest, were 0.9, 0.8, 1.3 (p=0.050). C st...Continue Reading

Citations

May 28, 2017·Journal of the American Heart Association·Ci SongAndrew D Johnson
Aug 9, 2017·PLoS Genetics·Abdou MousasAlexander P Reiner
Jul 21, 2020·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Xueya ZhangJingxin Pan
Nov 20, 2016·European Journal of Preventive Cardiology·Geoffrey H ToflerRalph B D'Agostino
Jun 4, 2020·Cells·Samantha WhiteKebin Hu
Mar 22, 2018·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Sallu JabatiMushabbar Syed
Nov 9, 2018·Frontiers in Pharmacology·Bee Ling TanHeshu Sulaiman Rahman
Oct 26, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Yuen-Kwun WongHung-Fat Tse
Dec 12, 2019·Frontiers in Physiology·Pamela CarmonaJosé Sarmiento
May 16, 2017·Metabolic Syndrome and Related Disorders·Omar BayomyGail K Adler
Oct 11, 2020·Cell Death and Differentiation·Toshifumi MatsuyamaTak W Mak
Sep 16, 2020·Cardiovascular Research·Luca LiberaleGiovanni G Camici
Dec 10, 2020·European Journal of Clinical Investigation·Rahim KanjiDiana A Gorog
Feb 13, 2021·Molecular and Cellular Biochemistry·Savalan Babapoor-FarrokhranSumeet K Mainigi
Jan 9, 2021·Frontiers in Cardiovascular Medicine·Machteld Sillen, Paul J Declerck
Apr 4, 2021·International Journal of Molecular Sciences·Machteld Sillen, Paul J Declerck
May 4, 2021·Frontiers in Cardiovascular Medicine·Gael B MorrowNicola J Mutch
Jun 7, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Sushmita Bora, Prashant Shankarrao Adole
Oct 19, 2021·Frontiers in Cardiovascular Medicine·Yuen-Kwun Wong, Hung-Fat Tse

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