Plasminogen Activator Inhibitor Type-1 as a Regulator of Fibrosis

Journal of Cellular Biochemistry
Reyhaneh RabieianHamed Mirzaei

Abstract

Fibrosis is known as a frequent and irreversible pathological condition which is associated with organ failure. Tissue fibrosis is a central process in a variety of chronic progressive diseases such as diabetes, hypertension, and persistent inflammation. This state could contribute to chronic injury and the initiation of tissue repair. Fibrotic disorders represent abnormal wound healing with defective matrix turnover and clearance that lead to excessive accumulation of extracellular matrix components. A variety of identified growth factors, cytokines, and persistently activated myofibroblasts have critical roles in the pathogenesis of fibrosis. Irrespective of etiology, the transforming growth factor-β pathway is the major driver of fibrotic response. Plasminogen activator inhibitor-1 (PAI-1) is a crucial downstream target of this pathway. Transforming growth factor-β positively regulates PAI-1 gene expression via two main pathways including Smad-mediated canonical and non-canonical pathways. Overexpression of PAI-1 reduces extracellular matrix degradation via perturbing the plasminogen activation system. Indeed, elevated PAI-1 levels inhibit proteolytic activity of tissue plasminogen activator and urokinase plasminogen activat...Continue Reading

References

Sep 21, 1994·Biochimica Et Biophysica Acta·O Sigurdardottir, B Wiman
Nov 26, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M SandströmR Henriksson
Feb 13, 2001·Biochemical and Biophysical Research Communications·D L CrandallT M Antrilli
Mar 16, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·C DongP J. Goldschmidt-Clermont
Mar 16, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·C DongP J. Goldschmidt-Clermont
Mar 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Chunming DongPascal J Goldschmidt-Clermont
Sep 17, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Chunming DongPascal J Goldschmidt-Clermont
Apr 17, 2003·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yoshihiro KamadaYuji Matsuzawa
Apr 18, 2003·American Journal of Hematology·Ion S JovinGert Müller-Berghaus
Apr 22, 2003·Journal of Cellular Physiology·Rohan Samarakoon, Paul J Higgins
May 10, 2003·Journal of Molecular and Cellular Cardiology·John A SchoenhardDouglas E Vaughan
Jun 17, 2003·Nature Structural Biology·Aiwu ZhouRandy J Read
Sep 17, 2004·Journal of Cellular Physiology·Rosalie R AllenPaul J Higgins
Sep 24, 2004·Current Medicinal Chemistry·Ann Gils, Paul J Declerck
Apr 22, 2005·British Journal of Haematology·Gabriela Cesarman-Maus, Katherine A Hajjar

❮ Previous
Next ❯

Citations

Jun 12, 2018·Epigenomics·Mohsen KeshavarzHamed Mirzaei
Jul 4, 2018·Journal of Cellular Physiology·Fahimeh Zamani RaraniBahman Rashidi
Aug 6, 2018·Journal of Cellular Physiology·Roghayyeh Vakili-GhartavolHamed Mirzaei
Aug 23, 2018·Journal of Cellular Biochemistry·Somaye NoruziHamed Mirzaei
Sep 8, 2018·Journal of Cellular Physiology·Elmira IranifarHamed Mirzaei
Sep 22, 2018·Journal of Cellular Physiology·Ghazaleh BaniebrahimiFatemeh Mir
Jun 21, 2018·Journal of Cellular Physiology·Leila JamaliHamed Mirzaei
Oct 27, 2018·International Journal of Cancer. Journal International Du Cancer·AmirReza HesariHamed Mirzaei
Oct 23, 2018·Journal of Neurochemistry·Pouria KhaniHamed Mirzaei
Dec 20, 2018·Journal of Cellular Physiology·Mohammad Javad Saeedi BorujeniAmid Yazdani
Feb 17, 2019·Journal of Cellular Biochemistry·Parvaneh SeiriMohammad Soukhtanloo
Feb 17, 2019·Journal of Cellular Biochemistry·AmirReza HesariFaezeh Ghasemi
Mar 3, 2019·Journal of Cellular Biochemistry·Zahra ZakeriSara Fadaei
May 14, 2019·Journal of Cellular Biochemistry·Hossein SharifiMohsen Taghizadeh
May 14, 2019·Journal of Cellular Biochemistry·Roozbeh Akbari MotlaghSeyed Mohammad Gheibi Hayat
Jun 21, 2019·Journal of Cellular Biochemistry·Abdolreza GhoreishyAmir Ghaemmaghami
Oct 17, 2019·IUBMB Life·Soheila MohammadiHamed Mirzaei
Nov 23, 2019·HIV Medicine·J Sadri NahandM R Hamblin
Dec 4, 2019·Journal of Drug Targeting·Mehwish Saba Aslam, Liudi Yuan
Sep 24, 2019·Current Medicinal Chemistry·Ehsan JavandoostHamid Reza Mirzaei
Apr 25, 2020·Expert Review of Anticancer Therapy·Huilin Zhang, Bingjian Lu
Jun 5, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Caiyun ZhengTingli Lu
Jun 22, 2020·Clinical and Translational Medicine·Lorelei D ShoemakerSteven D Chang
Feb 1, 2020·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Shota FurukawaYoko Nishitani
Jan 3, 2020·International Journal of Oncology·Marcela GallardoGloria M Calaf
Sep 5, 2019·Journal of Ovarian Research·Zahra ShabaninejadHamed Mirzaei
Sep 16, 2019·Journal of Translational Medicine·Shuaishuai XuLiang Liu
Jun 20, 2020·Archives of Pathology & Laboratory Medicine·Yang FeiWenjing Cao
Dec 7, 2018·Journal of Cellular Biochemistry·Amireza HesariFaezeh Ghasemi
Dec 12, 2018·Journal of Cellular Physiology·Javid Sadri NahandHossein Keyvani
Dec 15, 2018·Journal of Cellular Biochemistry·Hasan FarajipourMohsen Taghizadeh
Feb 3, 2019·International Journal of Molecular Sciences·Yosuke Kanno
Mar 13, 2019·Journal of Cellular Biochemistry·Parisa ZiaSarabiFaezeh Ghasemi
Aug 23, 2020·International Journal of Molecular Sciences·Machteld SillenPaul J Declerck
Mar 28, 2018·The Journal of Clinical Investigation·Neha PinchaColin Jamora
Dec 12, 2018·Journal of Cellular Biochemistry·Mostafa SarvizadehMohsen Taghizadeh
May 28, 2019·Journal of Cellular Biochemistry·Hossein SharifiMohsen Taghizadeh
Nov 26, 2019·American Journal of Physiology. Renal Physiology·Alena ParikovaOndrej Viklicky
Nov 14, 2019·Neurochemical Research·Vajihe AsgariHamid Bahramian
Nov 30, 2018·Journal of Cellular Biochemistry·AmirReza HesariFaezeh Ghasemi
Mar 25, 2020·Journal of Materials Science. Materials in Medicine·Nathan J ThyparambilJulie A Semon
Dec 6, 2018·Journal of Cellular Physiology·Rajab MardaniHossein Pourghadamyari

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Seminars in Thrombosis and Hemostasis
Panagiotis Flevaris, Douglas E Vaughan
International Journal of Molecular Medicine
Sylwia MałgorzewiczJerzy Jankun
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
P T StevensS M Stick
Journal of Medical and Dental Sciences
Mariko MatsushitaHiroo Yokozeki
© 2022 Meta ULC. All rights reserved