Plasminogen is tethered with high affinity to the cell surface by the plasma protein, histidine-rich glycoprotein.

The Journal of Biological Chemistry
Allison L JonesChristopher R Parish

Abstract

Plasminogen has been implicated in extracellular matrix degradation by invading cells, but few high affinity cell surface receptors for the molecule have been identified. Previous studies have reported that the plasma protein, histidine-rich glycoprotein (HRG), interacts with plasminogen and cell surfaces, raising the possibility that HRG may immobilize plasminogen/plasmin to cell surfaces. Here we show, based on optical biosensor analyses, that immobilized HRG interacts with soluble plasminogen with high affinity and with an extremely slow dissociation rate. Furthermore, the HRG-plasminogen interaction is lysine-dissociable and involves predominately the amino-terminal domain of HRG, and the fifth kringle domain of plasminogen, but not the carboxyl-terminal lysine of HRG. HRG was also shown to tether plasminogen to cell surfaces, with this interaction being potentiated by elevated Zn(2+) levels and low pH, conditions that prevail at sites of tissue injury, tumor growth, and angiogenesis. Based on these data we propose that HRG acts as a soluble adaptor molecule that binds to cells at sites of tissue injury, tumor growth, and angiogenesis, providing a high affinity receptor for tethering plasminogen to the cell surface and ther...Continue Reading

References

Nov 15, 1975·European Journal of Biochemistry·E E Rickli, W I Otavsky
Oct 1, 1991·The Journal of Clinical Investigation·J D VassalliD Belin
Oct 1, 1991·The Journal of Clinical Investigation·A P SappinoJ D Vassalli
Jan 1, 1985·Advances in Cancer Research·K DanøL Skriver
Apr 1, 1986·The Journal of Clinical Investigation·L L Leung
Oct 1, 1980·The Biochemical Journal·B Wiman
Oct 1, 1981·European Journal of Biochemistry·D B RylattC R Parish
Jul 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E F PlowJ L Hoover-Plow
Mar 1, 1993·American Journal of Hematology·R GorodetskyG Marx
Mar 20, 1999·The Journal of Biological Chemistry·P StathakisP J Hogg
Nov 11, 1999·British Journal of Haematology·A ScherrerA P Sappino
Feb 9, 2000·Trends in Biochemical Sciences·M A ParryI Bode
May 19, 2000·Methods : a Companion to Methods in Enzymology·V A Ploplis, F J Castellino
May 19, 2000·Methods : a Companion to Methods in Enzymology·K LähteenmäkiT K Korhonen
Jul 20, 2001·Annals of the New York Academy of Sciences·H R Lijnen
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nick N GorganiArgyrios N Theofilopoulos
Jan 1, 2004·The Journal of Clinical Investigation·Qi LingKatherine A Hajjar
May 13, 2004·The Journal of Biological Chemistry·Allison L JonesChristopher R Parish

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Mar 25, 2006·Future Oncology·Daniel Keppler, Felipe Sierra
Dec 8, 2010·Cellular and Molecular Life Sciences : CMLS·Johann Schaller, Simon S Gerber
Aug 11, 2015·Proteomics. Clinical Applications·Frances ZenónHoracio Serrano
May 5, 2005·Journal of Thrombosis and Haemostasis : JTH·D-B Borza
May 5, 2005·Journal of Thrombosis and Haemostasis : JTH·N Tsuchida-StraetenW Jahnen-Dechent
Aug 29, 2009·The Biochemical Journal·Ivan K H PoonChristopher R Parish
Aug 2, 2011·Journal of Proteomics·Anne von ZychlinskiSally P McCormick
Dec 4, 2014·Cytokine & Growth Factor Reviews·Marco Rusnati, Marco Presta
Oct 26, 2010·Blood·Ivan K H PoonMark D Hulett
May 24, 2016·Reproductive Biomedicine Online·Karin E LindgrenHelena Åkerud
Jan 29, 2011·Circulation Research·Vladimir LeksaHannes Stockinger
Oct 28, 2005·Journal of Molecular Recognition : JMR·Rebecca L Rich, David G Myszka
Dec 28, 2019·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Letizia MattiiAntonietta R M Sabbatini
Mar 17, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anoop Singh ChauhanManoj Raje
May 8, 2020·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Hidenori Wake, Masahiro Nishibori
Jan 9, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Peng YangHan-Qing Li
Aug 8, 2020·International Journal of Molecular Sciences·Valeria VerdeDiego La Mendola
Sep 30, 2009·Journal of Inorganic Biochemistry·Attila JancsóTamás Gajda

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