Plasmodia express two threonine-peptidase complexes during asexual development

Molecular and Biochemical Parasitology
Benjamin MordmüllerPeter G Kremsner

Abstract

Threonine-peptidases of the T1-family are multi-subunit complexes with broad substrate specificity. In eukaryotes, at least 14 genes encode subunits of the prototypic T1 threonine-peptidase, the proteasome. The proteasome determines the turnover of most proteins and thereby plays a fundamental role in diverse processes such as protein quality control, signal transduction, and cell cycle regulation. While eukaryotes and archaea possess a proteasome, bacteria generally express a second member of the T1-family, the proteasomal predecessor ClpQ/hslV that has a similar structure but is encoded by only one gene. The plasmodial genome is an exception because it encodes proteasomal subunits as well as a ClpQ/hslV-orthologe (Plasmodium falciparum-hslV; PfhslV). Structure, expression, and function of both types of peptidase-complex in P. falciparum are presently unknown. Our aim was to analyze both the coding sequences and derived proteins of both peptidase-complexes because highly specific and potent inhibitors can be designed against this class of enzymes. The proteasome was found expressed throughout the cell cycle, whereas PfhslV was detectable in schizonts and merozoites only. Treatment of P. falciparum with the threonine-peptidase ...Continue Reading

Citations

Aug 5, 2009·Antimicrobial Agents and Chemotherapy·Beata CzesnyKim C Williamson
May 22, 2013·Antimicrobial Agents and Chemotherapy·Serena TschanBenjamin Mordmüller
Apr 14, 2010·Wiener klinische Wochenschrift·Benjamin Mordmüller
Apr 14, 2010·Wiener klinische Wochenschrift·Peter Gottfried Kremsner
Jun 22, 2010·International Journal for Parasitology·Serena TschanBenjamin Mordmüller
Nov 10, 2009·Veterinary Parasitology·Mahmoud AboulailaIkuo Igarashi
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Mar 21, 2019·Frontiers in Microbiology·Manasi MishraShailja Singh

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