Plasmodium berghei crystalloids contain multiple LCCL proteins.

Molecular and Biochemical Parasitology
Sadia SaeedJ T Dessens

Abstract

Malaria crystalloids are unique organelles of unknown function that are present only in the mosquito-specific ookinete and early oocyst stages of the parasite. Recently, crystalloid formation in Plasmodium berghei was linked to the parasite protein PbSR, a member of the Plasmodium LCCL protein family composed of six modular multidomain proteins involved in sporozoite development and infectivity. Here, we show by fluorescent protein tagging that two other LCCL protein family members are targeted to the crystalloids in a similar way to PbSR. These results extend the similarities between the LCCL proteins, and provide strong supporting evidence for the hypothesis that members of this protein family work in concert and are involved in a similar molecular process.

Citations

Apr 27, 2010·Medical Microbiology and Immunology·Andrea KuehnGabriele Pradel
Jul 18, 2012·The American Journal of Tropical Medicine and Hygiene·Kailash P Patra, Joseph M Vinetz
Sep 5, 2014·Parasitology Research·Annie Z TrempJohannes T Dessens
Jun 19, 2013·Molecular Microbiology·Annie Z TrempJohannes T Dessens
Aug 11, 2012·Molecular and Biochemical Parasitology·Sadia SaeedJohannes T Dessens
Apr 23, 2015·International Journal for Parasitology·Sadia SaeedJohannes T Dessens
May 21, 2013·Molecular and Biochemical Parasitology·Sadia SaeedJohannes T Dessens
Jan 18, 2011·Trends in Parasitology·Johannes T DessensVictoria Carter
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Methods Mentioned

BETA
PCR
transfection

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