Plasmodium berghei: inhibition of the sporogonous cycle by alpha-difluoromethylornithine

Experimental Parasitology
J GilletP L Mulamba

Abstract

alpha-Difluoromethylornithine (DFMO), an enzyme inhibitor of ornithine decarboxylase, inhibits the sporogonous cycle of the malaria parasite Plasmodium berghei in the mosquito vector Anopheles stephensi. DFMO was administered to the mosquitoes dissolved either in the sugar solution at their disposal in the cages or through blood meals taken from treated mice. The mice subsequently bitten by mosquitoes treated with DFMO by both routes of administration did not contract malaria.

References

Jan 1, 1982·Transactions of the Royal Society of Tropical Medicine and Hygiene·J M GilletF Herman

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Citations

Apr 27, 2001·Trends in Parasitology·S MüllerR D Walter
Aug 1, 1985·Experimental Parasitology·M R HollingdaleA Sjoerdsma
Sep 30, 2016·Scientific Reports·Yesseinia I Angleró-RodríguezGeorge Dimopoulos
Nov 1, 1986·The Journal of protozoology·K KaurB Ullman
Jul 1, 1987·Drug Intelligence & Clinical Pharmacy·K J TietzeE M Cosgrove
Aug 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Diana FontinhaMiguel Prudêncio

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