Plasmodium falciparum accompanied the human expansion out of Africa.

Current Biology : CB
Kazuyuki TanabeFrancois Balloux

Abstract

Plasmodium falciparum is distributed throughout the tropics and is responsible for an estimated 230 million cases of malaria every year, with a further 1.4 billion people at risk of infection. Little is known about the genetic makeup of P. falciparum populations, despite variation in genetic diversity being a key factor in morbidity, mortality, and the success of malaria control initiatives. Here we analyze a worldwide sample of 519 P. falciparum isolates sequenced for two housekeeping genes (63 single nucleotide polymorphisms from around 5000 nucleotides per isolate). We observe a strong negative correlation between within-population genetic diversity and geographic distance from sub-Saharan Africa (R(2) = 0.95) over Africa, Asia, and Oceania. In contrast, regional variation in transmission intensity seems to have had a negligible impact on the distribution of genetic diversity. The striking geographic patterns of isolation by distance observed in P. falciparum mirror the ones previously documented in humans and point to a joint sub-Saharan African origin between the parasite and its host. Age estimates for the expansion of P. falciparum further support that anatomically modern humans were infected prior to their exit out of A...Continue Reading

References

Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·A A Escalante, F J Ayala
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·S M RichF J Ayala
Jul 21, 2001·Science·S K VolkmanD L Hartl
Jan 14, 2003·Genetics·Mark A BeaumontDavid J Balding
Apr 12, 2003·Science·Deirdre A JoyXin-zhuan Su
Aug 22, 2003·Nature·U Eckstein-LudwigS Krishna
Dec 12, 2003·Bioinformatics·Julio RozasRicardo Rozas
Mar 24, 2004·Nature Reviews. Microbiology·Daniel L Hartl
Jul 21, 2004·Briefings in Bioinformatics·Sudhir KumarMasatoshi Nei
Mar 9, 2005·Current Biology : CB·Franck PrugnolleFrançois Balloux
Sep 8, 2005·PLoS Biology·Jianbing MuXin-zhuan Su
Sep 29, 2005·Human Genetics·Andrea ManicaFrançois Balloux
Oct 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sohini RamachandranL Luca Cavalli-Sforza
Jul 11, 2006·American Journal of Human Genetics·Hua LiuFrançois Balloux
Dec 13, 2006·Nature Genetics·Daniel C JeffaresMatthew Berriman
Dec 13, 2006·Nature Genetics·Sarah K VolkmanDyann F Wirth
Mar 16, 2007·The Journal of Infectious Diseases·Marcelo U FerreiraDaniel L Hartl
Jul 20, 2007·Nature·Andrea ManicaTsunehiko Hanihara
Jul 28, 2007·Trends in Genetics : TIG·Lori J Lawson HandleyFrançois Balloux
Aug 9, 2008·Molecular Biology and Evolution·Toshiyuki HayakawaKazuyuki Tanabe
Sep 4, 2008·Heredity·I G RomeroF Balloux
Sep 18, 2008·Proceedings. Biological Sciences·Omkar DeshpandeL Luca Cavalli-Sforza
Mar 28, 2009·PLoS Medicine·Simon I HayRobert W Snow
May 30, 2009·PLoS Pathogens·Benjamin OllomoFrançois Renaud
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Stephen M RichNathan D Wolfe

❮ Previous
Next ❯

Citations

Dec 2, 2010·Parasitology·Joana C SilvaAustin L Hughes
May 9, 2012·Proceedings of the National Academy of Sciences of the United States of America·Vera WarmuthAndrea Manica
Dec 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Erhan YalcindagFranck Prugnolle
Oct 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·Brenna M HennMarcus W Feldman
Apr 20, 2013·Science·Paul M SharpBeatrice H Hahn
Nov 23, 2011·Genome Biology·Vincenza ColonnaChris Tyler-Smith
Mar 9, 2011·PLoS Pathogens·Franck PrugnolleFrançois Renaud
Nov 4, 2011·Genetics·E SchaperB Mehlig
Apr 4, 2012·Emerging Infectious Diseases·Milan JirkůJulius Lukeš
Feb 22, 2014·Nature Communications·Weimin LiuPaul M Sharp
Jul 7, 2011·Proceedings of the National Academy of Sciences of the United States of America·Franck PrugnolleFrançois Renaud
Nov 8, 2014·Proceedings. Biological Sciences·Amanda A PierceJacobus C de Roode
Feb 13, 2013·The American Journal of Tropical Medicine and Hygiene·Alyssa E BarryJohn C Reeder
Dec 30, 2015·Proceedings of the National Academy of Sciences of the United States of America·Brenna M HennCarlos D Bustamante
Jul 30, 2014·Parasitology International·Richard L Culleton, Hussein M Abkallo
Jul 12, 2011·Acta Tropica·Myriam Arevalo-HerreraSocrates Herrera
Mar 5, 2016·ELife·UNKNOWN MalariaGEN Plasmodium falciparum Community Project
May 29, 2012·IUBMB Life·Janina PreussKatja Becker
Jan 30, 2015·Evolutionary Anthropology·George H Perry
Nov 19, 2015·Malaria Journal·Jean-Marc ChavatteRaymond Tzer Pin Valentine Lin
Jun 7, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·A M PaquetteJ A Wilder
May 24, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·A MercierM-L Dardé
Apr 29, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Bita BordbarAudrey Sabbagh
Jun 10, 2014·Theoretical Population Biology·M RafajlovićB Mehlig
Sep 4, 2014·Frontiers in Public Health·Ranjan Ramasamy
Sep 19, 2014·Frontiers in Cellular and Infection Microbiology·Julio Gallego-Delgado, Ana Rodriguez
Sep 10, 2014·The Journal of Parasitology·Dante S ZarlengaGiuseppe Nascetti
Jul 20, 2016·Proceedings of the National Academy of Sciences of the United States of America·Alexander H Harcourt
Oct 16, 2016·Current Opinion in Genetics & Development·Lauren Alpert Sugden, Sohini Ramachandran
Jan 16, 2015·Molecular Biology and Evolution·Joana C SilvaDavid G Harris
Sep 4, 2014·Memórias do Instituto Oswaldo Cruz·Alvaro Molina-Cruz, Carolina Barillas-Mury
Jul 31, 2014·Memórias do Instituto Oswaldo Cruz·Suchi TyagiAparup Das

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.