Plasmodium falciparum: adherence of the parasite-infected erythrocytes to chondroitin sulfate proteoglycans bearing structurally distinct chondroitin sulfate chains

Experimental Parasitology
Arivalagan MuthusamyD Channe Gowda

Abstract

Infection with Plasmodium falciparum during pregnancy leads to the selective adherence of infected red blood cells (IRBCs) in the placenta causing placental malaria. The IRBC adherence is mediated through the chondroitin 4-sulfate (C4S) chains of unusually low-sulfated chondroitin sulfate proteoglycans (CSPGs) in the placenta. To study the structural interactions involved in C4S-IRBC adherence, various investigators have used CSPGs from different sources. Since the structural characteristics of the polysaccharide chains in CSPGs from various sources differ substantially, the CSPGs are likely to differentially bind IRBCs. In this study, the CSPG purified from bovine trachea, a CSPG form of human recombinant thrombomodulin (TM-CSPG), two CSPG fractions from bovine cornea, and the CSPGs of human placenta, the natural receptor, were studied in parallel for their IRBC binding characteristics. The TM-CSPG and corneal CSPG fractions could bind IRBCs at significantly higher density compared to the placental CSPGs. However, the avidity of IRBC binding by TM-CSPG was considerably low compared to placental CSPGs. The corneal CSPGs have substantially higher binding strengths. The bovine tracheal CSPG bound IRBCs at much lower density and e...Continue Reading

References

Feb 8, 2002·Nature·Louis H MillerOgobara K Doumbo
Jan 10, 2003·Acta Obstetricia Et Gynecologica Scandinavica·Bjørg Evjen OlsenGunnar Kvåle
Aug 28, 2003·Current Opinion in Microbiology·Patrick E Duffy, Michal Fried

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Citations

Apr 22, 2011·Trends in Parasitology·Suchi Goel, D Channe Gowda
Apr 26, 2006·Clinical and Experimental Immunology·E RindsjöA Scheynius
Jan 24, 2007·Advances in Pharmacology·D Channe Gowda
Jan 24, 2007·Advances in Pharmacology·Luiz-Claudio F Silva

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