PMID: 7538019Dec 1, 1994Paper

Plasmodium falciparum: CD36 dependent cytoadherence or rosetting of infected erythrocytes is modulated by knobs

Cell Adhesion and Communication
I CrandallI W Sherman

Abstract

A knobless (K-) line of the FCR-3 isolate of Plasmodium falciparum was obtained by gelatin flotation. Immunofluorescent staining and immunoblots indicated that both the K- line and the K+ (knobby) line from which it was derived contained similar forms of potentially adhesive modified band 3 protein. When the K+ and K- lines were assayed for their cytoadherent and rosetting abilities the K+ line showed a high level of CD36 dependent cytoadherence, whereas the K- line demonstrated a marked pH dependent increase in rosetting. Rosetting was inhibited by the addition of peptides based on band 3 motifs, suggesting that cytoadherence and rosetting involve the same adhesin but that the presence of knobs affects whether the adherent preference of the infected erythrocyte is uninfected red cells or endothelial/C32 amelanotic melanoma cells.

References

Feb 1, 1978·Annals of Tropical Medicine and Parasitology·G PasvolJ Brown
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Aug 20, 1976·Science·W Trager, J B Jensen
Nov 1, 1992·The Journal of Experimental Medicine·J Carlson, M Wahlgren
Jun 1, 1992·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·K K CarrollK Ravi
May 1, 1992·The American Journal of Tropical Medicine and Hygiene·W RuangjirachupornM Wahlgren
Jun 1, 1990·The Journal of Experimental Medicine·B A BiggsJ H Leech
Jun 1, 1991·Parasitology·W RuangjirachupornP Perlmann
Feb 1, 1991·The American Journal of Tropical Medicine and Hygiene·E PongponratnM Aikawa
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J CarlsonM Wahlgren
Aug 1, 1990·The American Journal of Tropical Medicine and Hygiene·M AikawaR J Howard
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B A BiggsG V Brown
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·A IsraeliM A Ephros
Mar 1, 1988·The American Journal of Tropical Medicine and Hygiene·P H DavidK N Mendis
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·K P DayD J Kemp
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·I CrandallI W Sherman
Jan 1, 1994·Parasitology Today·M WahlgrenJ Carlson

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Citations

Oct 1, 1995·Parasitology Today·I W ShermanK M Land
Sep 7, 2001·Annual Review of Microbiology·S KyesC Newbold
Aug 30, 2005·Anais Da Academia Brasileira De Ciências·Karin Kirchgatter, Hernando A Del Portillo
Jun 1, 2005·Journal of Cell Science·Paul HorrocksChris I Newbold

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