Plasmodium falciparum induces a Th1/Th2 disequilibrium, favoring the Th1-type pathway, in the human placenta

The Journal of Infectious Diseases
Nadine FievetGérard Chaouat

Abstract

During pregnancy, a local and systemic Th2 bias of maternal immunity favors Th1-dependent infections such as malaria. This study measured cytokines secreted in cultures of chorionic villi, placental blood cells (PBC), and serum in term placentas from 88 malaria-infected and -noninfected Cameroon women. Interleukin (IL)--2 and --4 were consistently low; IL-1 beta, IL-6, granulocyte-macrophage colony-stimulating factor, and transforming growth factor (TGF)--beta 2 were highest in villi cultures. Tumor necrosis factor (TNF)--alpha, interferon (IFN)--gamma, and IL-10 were highest in PBC cultures. Malaria placental infection increased Th1-type cytokines, whereas Th2-type cytokines and TGF-beta 2 were unchanged. Addition of lipopolysaccharide or infected erythrocytes to cultures increased TNF-alpha, IL-1 beta, IL-6, and IL-10 secretions but not those of IFN-gamma and IL-4. Overall, Plasmodium falciparum induced a placental immune response involving both Th1- and Th2-type cell activation. Although the Th1 pathway was favored, IL-10 secretion was also increased, and this increase should be effective in protecting the placenta by controlling the negative effects of Th1 cytokines on pregnancy.

Citations

Jun 2, 2006·Springer Seminars in Immunopathology·Sinuhe HahnWolfgang Holzgreve
Nov 19, 2003·Biochemical and Biophysical Research Communications·Douglas J PerkinsAltaf A Lal
Apr 15, 2004·Placenta·B J BrabinJ Ordi
Apr 10, 2002·Scandinavian Journal of Immunology·K R ShadidiT Aarvak
Jan 11, 2011·The Journal of Infectious Diseases·Alexandra J UmbersStephen J Rogerson
Jul 21, 2007·Journal of Biomedicine & Biotechnology·Nicaise Tuikue Ndam, Philippe Deloron
Mar 4, 2008·Malaria Journal·Naomi W LucchiJulie M Moore
Jul 3, 2008·Retrovirology·Guillermina Laura DolciniLiliana Martínez Peralta
Jul 13, 2014·Human Reproduction Update·Azure N FaucetteKang Chen
Dec 25, 2007·Wiener klinische Wochenschrift·Ayola A AdegnikaPeter G Kremsner
Mar 8, 2011·Trends in Parasitology·Alexandra J UmbersStephen J Rogerson
Jul 8, 2010·Trends in Parasitology·Lars HviidCarlos Penha-Gonçalves
Oct 12, 2010·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Petra F MensHenk D F H Schallig
Dec 3, 2009·Médecine et maladies infectieuses·G Martin-BlondelB Marchou
Jul 20, 2005·Acta Obstetricia Et Gynecologica Scandinavica·Minyue DongHanzhi Wang
Jul 28, 2004·American Journal of Reproductive Immunology : AJRI·Elizabeth T AbramsSteven R Meshnick
Mar 12, 2005·American Journal of Reproductive Immunology : AJRI·Morgan R Peltier, Mary B Brown
Mar 27, 2009·American Journal of Human Biology : the Official Journal of the Human Biology Council·Elizabeth T Abrams, Steven R Meshnick
Jun 1, 2005·Trends in Parasitology·Renée M NedVenkatachalam Udhayakumar
Nov 4, 2006·Molecular and Biochemical Parasitology·Kelly BroenAdrian J F Luty
Mar 4, 2015·Biomarkers in Medicine·Esmée RuizendaalPetra F Mens
May 28, 2016·Journal of Diabetes and Its Complications·Lauren Wedekind, Louiza Belkacemi
Jun 24, 2015·The American Journal of Tropical Medicine and Hygiene·Samad A IbitokouNicaise Tuikue Ndam
Jan 25, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kee Thai YeoArlene Dent
Sep 29, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jayakumar S PoovasseryJulie M Moore
Oct 29, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Audrey Davidson ThévenonDiane Wallace Taylor

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.