Plasmodium falciparum Infection Does Not Affect Human Immunodeficiency Virus Viral Load in Coinfected Rwandan Adults

Open Forum Infectious Diseases
Krishanthi SubramaniamJohanna P Daily

Abstract

Plasmodium falciparum infection has been reported to increase human immunodeficiency virus (HIV) viral load (VL), which can facilitate HIV transmission. We prospectively studied the impact of mild P falciparum coinfection on HIV VL in Rwanda. We measured plasma HIV VL at presentation with malaria infection and weekly for 4 weeks after artemether-lumefantrine treatment in Rwandan adults infected with HIV with P falciparum malaria. Regression analyses were used to examine associations between malaria infection and HIV VL changes. Samples with detectable virus underwent genotypic drug-resistance testing. We enrolled 28 HIV-malaria coinfected patients and observed 27 of them for 5 weeks. Three patients (11%) were newly diagnosed with HIV. Acute P falciparum infection had no significant effect on HIV VL slope over 28 days of follow-up. Ten patients with VL <40 copies/mL at enrollment maintained viral suppression throughout. Seventeen patients had a detectable VL at enrollment including 9 (53%) who reported 100% adherence to ARVs; 3 of these had detectable genotypic drug resistance. Unlike studies from highly malaria-endemic areas, we did not identify an effect of P falciparum infection on HIV VL; therefore, malaria is not likely to ...Continue Reading

References

Mar 30, 2012·The Journal of Infectious Diseases·Amara E EzeamamaWafaie W Fawzi
Aug 3, 2013·The Journal of Infectious Diseases·Jessica M FogelSusan H Eshleman
Oct 5, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mark A MarzinkeJessica M Fogel

❮ Previous
Next ❯

Citations

Feb 27, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Regina JoiceDanny A Milner

❮ Previous
Next ❯

Methods Mentioned

BETA
blood
Assay
genotyping

Software Mentioned

SAS
STATA

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.